Intron 22-specific long PCR for the Xba I polymorphism in the factor VIII gene

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dc.contributor.author El Maarri, Osman
dc.contributor.author Oldenburg, Johannes
dc.contributor.author Caglayan, S.Hande
dc.date.accessioned 2017-09-12T06:49:24Z
dc.date.available 2017-09-12T06:49:24Z
dc.date.copyright 1999 en_US
dc.date.issued 2017-09-12
dc.identifier.issn 1365-2141 en_US
dc.identifier.uri http://hdl.handle.net/10725/6162
dc.description.abstract The Xba I polymorphic site in the factor VIII gene is present in the int22h-1 region which is found in two other copies (int22h-2 and int22h-3) distal to the gene. Previously the polymorphic status of the Xba I locus was studied by either Southern blot or PCR that amplified all three copies. Here we report the use of a long PCR that specifically amplifies the intragenic site in intron 22, making use of this marker an easy and reliable assay. Moreover, about 25% of previously uninformative Turkish haemophilia A families examined with three markers proved to be informative for linkage analysis, using the Xba I polymorphism. en_US
dc.language.iso en en_US
dc.title Intron 22-specific long PCR for the Xba I polymorphism in the factor VIII gene en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201508713 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal British journal of Haematology en_US
dc.journal.volume 105 en_US
dc.journal.issue 4 en_US
dc.article.pages 1120-1122 en_US
dc.identifier.doi http://dx.doi.org/10.1046/j.1365-2141.1999.01430.x en_US
dc.identifier.ctation El‐Maarri, O., Oldenburg, J., & Çağlayan, S. H. (1999). Intron 22‐specific long PCR for the Xba I polymorphism in the factor VIII gene. British journal of haematology, 105(4), 1120-1122. en_US
dc.author.email osman.elmaarri@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.1999.01430.x/full en_US
dc.author.affiliation Lebanese American University en_US

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