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| dc.contributor.author | El Maarri, Osman | |
| dc.contributor.author | Oldenburg, Johannes | |
| dc.contributor.author | Caglayan, S.Hande | |
| dc.date.accessioned | 2017-09-12T06:49:24Z | |
| dc.date.available | 2017-09-12T06:49:24Z | |
| dc.date.copyright | 1999 | en_US |
| dc.date.issued | 2017-09-12 | |
| dc.identifier.issn | 1365-2141 | en_US |
| dc.identifier.uri | http://hdl.handle.net/10725/6162 | |
| dc.description.abstract | The Xba I polymorphic site in the factor VIII gene is present in the int22h-1 region which is found in two other copies (int22h-2 and int22h-3) distal to the gene. Previously the polymorphic status of the Xba I locus was studied by either Southern blot or PCR that amplified all three copies. Here we report the use of a long PCR that specifically amplifies the intragenic site in intron 22, making use of this marker an easy and reliable assay. Moreover, about 25% of previously uninformative Turkish haemophilia A families examined with three markers proved to be informative for linkage analysis, using the Xba I polymorphism. | en_US |
| dc.language.iso | en | en_US |
| dc.title | Intron 22-specific long PCR for the Xba I polymorphism in the factor VIII gene | en_US |
| dc.type | Article | en_US |
| dc.description.version | Published | en_US |
| dc.author.school | SAS | en_US |
| dc.author.idnumber | 201508713 | en_US |
| dc.author.department | Natural Sciences | en_US |
| dc.description.embargo | N/A | en_US |
| dc.relation.journal | British journal of Haematology | en_US |
| dc.journal.volume | 105 | en_US |
| dc.journal.issue | 4 | en_US |
| dc.article.pages | 1120-1122 | en_US |
| dc.identifier.doi | http://dx.doi.org/10.1046/j.1365-2141.1999.01430.x | en_US |
| dc.identifier.ctation | El‐Maarri, O., Oldenburg, J., & Çağlayan, S. H. (1999). Intron 22‐specific long PCR for the Xba I polymorphism in the factor VIII gene. British journal of haematology, 105(4), 1120-1122. | en_US |
| dc.author.email | osman.elmaarri@lau.edu.lb | en_US |
| dc.identifier.tou | http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php | en_US |
| dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.1999.01430.x/full | en_US |
| dc.author.affiliation | Lebanese American University | en_US |
