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The role of OM-85 BV (Broncho-Vaxom) in preventing recurrent acute tonsillitis in children

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dc.contributor.author Saade, Rami
dc.contributor.author Bitar, Mohamed A.
dc.date.accessioned 2017-09-07T06:35:21Z
dc.date.available 2017-09-07T06:35:21Z
dc.date.copyright 2013 en_US
dc.identifier.issn 1872-8464 en_US
dc.identifier.uri http://hdl.handle.net/10725/6149
dc.description.abstract To evaluate the efficacy of an immunostimulant (bacterial lysate) Broncho-Vaxom in the management of children with recurrent acute tonsillitis. Methods A 5-year retrospective cohort study of 177 children presenting with a diagnosis of recurrent acute tonsillitis. Patients’ demographics and laboratory studies at presentation were retrieved. For patients given Broncho-Vaxom, we defined response as a decrease in the frequency of acute tonsillitis episodes after 3 months of therapy (partial: by ≤50% and total: by >50%). Patients showing response to Broncho-Vaxom were further followed until study-end or need for tonsillectomy. Results The median age of patients was 4.5 years (range: 1–15 years) with 63.8% being males. 131 (74%) patients received Broncho-Vaxom as initial therapy, and 99 (75.6%) showed response (51.2% total and 24.4% partial response). A normal ESR level was the only predictor of total compared with no response (OR: 3.53, 95% CI: 1.03–12.07); while both normal ESR (OR: 7.15-times, 95% CI: 1.18–43.39) and normal CRP (OR: 12.66, 95% CI: 1.43–111.86) levels were independent predictors of total over partial response. None of the patients showing total response required tonsillectomy on long-term follow up while in those with partial response 34.4% required subsequent tonsillectomy (median follow-up: 9 months). Conclusions A considerable proportion of children receiving Broncho-Vaxom for recurrent acute tonsillitis show a decrease in the frequency of episodes in the short term, and very few patients eventually require tonsillectomy on long-term follow up en_US
dc.language.iso en en_US
dc.title The role of OM-85 BV (Broncho-Vaxom) in preventing recurrent acute tonsillitis in children en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 200102768 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Pediatric Otorhinolaryngology en_US
dc.journal.volume 77 en_US
dc.journal.issue 5 en_US
dc.article.pages 670-673 en_US
dc.identifier.doi https://doi.org/10.1016/j.ijporl.2013.01.009 en_US
dc.identifier.ctation Bitar, M. A., & Saade, R. (2013). The role of OM-85 BV (Broncho-Vaxom) in preventing recurrent acute tonsillitis in children. International journal of pediatric otorhinolaryngology, 77(5), 670-673. en_US
dc.author.email rami.saade@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0165587613000207 en_US
dc.author.affiliation Lebanese American University en_US


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