Modulation of caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins

Sleiman, Sama F.; Sun, Hongliu; Nehms, Brian L.; Chamberlin, Helen M.; Hanna-Rose, Wendy

Modulation of caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins

Sleiman, Sama F.; Sun, Hongliu; Nehms, Brian L.; Chamberlin, Helen M.; Hanna-Rose, Wendy

URI: http://hdl.handle.net/10725/6144

URL: http://www.genetics.org/content/177/2/1221

DOI: https://doi.org/10.1534/genetics.107.070847

Date: 2017-09-06

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Abstract:

The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the DNA-binding domains of at least four other transcription factors, suggesting broad regulatory activity by HIM-8.

Citation:

Sun, H., Nelms, B. L., Sleiman, S. F., Chamberlin, H. M., & Hanna-Rose, W. (2007). Modulation of Caenorhabditis elegans transcription factor activity by HIM-8 and the related Zinc-Finger ZIM proteins. Genetics, 177(2), 1221-1226.