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Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators

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dc.contributor.author Sleiman, Sama F.
dc.contributor.author Speer, Rachel E.
dc.contributor.author Karuppagounder, Savaranan S.
dc.contributor.author Basso, Manuela
dc.contributor.author Kumar, Amit
dc.contributor.author Brand, David
dc.contributor.author Smirnova, Natalya
dc.contributor.author Gazaryan, Irina
dc.contributor.author Khim, Soah J.
dc.date.accessioned 2017-09-05T13:18:15Z
dc.date.available 2017-09-05T13:18:15Z
dc.date.copyright 2013 en_US
dc.identifier.issn 1873-4596 en_US
dc.identifier.uri http://hdl.handle.net/10725/6136
dc.description.abstract Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for these conditions have historically had poor success in translating from bench to bedside. Hypoxia-inducible factor (HIF)-1α mediates a broad, evolutionarily conserved, endogenous adaptive program to hypoxia, and manipulation of components of the HIF pathway is neuroprotective in a number of human neurological diseases and experimental models. In this review, we discuss molecular components of one aspect of hypoxic adaptation in detail and provide perspective on which targets within this pathway seem to be ripest for preventing and repairing neurodegeneration. Further, we highlight the role of HIF prolyl hydroxylases as emerging targets for the salutary effects of metal chelators on ferroptosis in vitro as well in animal models of neurological diseases. en_US
dc.language.iso en en_US
dc.title Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle from ferroptosis to stroke en_US
dc.author.school SAS en_US
dc.author.idnumber 201408170 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Free Radical Biology and Medicine en_US
dc.journal.volume 62 en_US
dc.article.pages 26-36 en_US
dc.keywords Metal chelators en_US
dc.keywords Neurodegeneration en_US
dc.keywords Hypoxia-inducible factors en_US
dc.keywords Transcription en_US
dc.keywords Prolyl hydroxylases en_US
dc.keywords Free radicals en_US
dc.identifier.doi https://doi.org/10.1016/j.freeradbiomed.2013.01.026 en_US
dc.identifier.ctation Speer, R. E., Karuppagounder, S. S., Basso, M., Sleiman, S. F., Kumar, A., Brand, D., ... & Ratan, R. R. (2013). Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators: From ferroptosis to stroke. Free Radical Biology and Medicine, 62, 26-36. en_US
dc.author.email sama.sleiman@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0891584913000361 en_US
dc.author.affiliation Lebanese American University en_US


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