Looking above but not beyond the genome for therapeutics in neurology and psychiatry

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dc.contributor.author Sleiman, Sama
dc.contributor.author Ratan, Rajiv R.
dc.contributor.author Basso, Manuela
dc.date.accessioned 2017-09-05T12:58:44Z
dc.date.available 2017-09-05T12:58:44Z
dc.date.copyright 2013 en_US
dc.identifier.issn 1878-7479 en_US
dc.identifier.uri http://hdl.handle.net/10725/6134
dc.description.abstract We welcome you to a special issue of Neurotherapeutics that highlights much of the exciting new thinking behind a burgeoning and therapeutically relevant topic—epigenetic proteins in psychiatric and neurological disease. It is now well established that expression of single genes or gene cassettes is determined by the interplay between transcription factors and epigenetic modulators. Epigenetics literally means “above the genome” and is defined by modifications of DNA, as well as chromatin that ultimately affect gene expression. Accordingly, epigenetic markers can be considered similar to punctuation marks in the English language. They define the beginning and the end of a gene; they structure the chromosomes; and they alter how the information is read, either activating or silencing transcription. en_US
dc.language.iso en en_US
dc.title Looking above but not beyond the genome for therapeutics in neurology and psychiatry en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle epigenetic proteins and RNAs find a new focus en_US
dc.author.school SAS en_US
dc.author.idnumber 201408170 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Neurotherapeutics en_US
dc.journal.volume 10 en_US
dc.journal.issue 4 en_US
dc.article.pages 551-555 en_US
dc.identifier.doi http://dx.doi.org/10.1007/s13311-013-0225-2 en_US
dc.identifier.ctation Basso, M., Sleiman, S., & Ratan, R. R. (2013). Looking above but not beyond the genome for therapeutics in neurology and psychiatry: epigenetic proteins and RNAs find a new focus. en_US
dc.author.email sama.sleiman@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://link.springer.com/content/pdf/10.1007%2Fs13311-013-0225-2.pdf en_US
dc.author.affiliation Lebanese American University en_US

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