Luteal supplementation in in vitro fertilization: more questions than answers

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dc.contributor.author Hubayter, Ziad R.
dc.contributor.author Muasher, Suheil J.
dc.date.accessioned 2017-09-05T06:17:48Z
dc.date.available 2017-09-05T06:17:48Z
dc.date.copyright 2008 en_US
dc.date.issued 2017-09-05
dc.identifier.issn 1556-5653 en_US
dc.identifier.uri http://hdl.handle.net/10725/6121
dc.description.abstract Objective To update clinicians on different regimens of luteal phase supplementation in IVF-stimulated cycles and to identify areas that need further research in this subject. Design Literature review and critical analysis of published studies on luteal phase supplementation during the last 20 years. Conclusion(s) Luteal phase supplementation in IVF-stimulated cycles, both in gonadotropin releasing hormone agonist and antagonist protocols, is considered an essential requirement for optimal success rates. The date of initiation and discontinuation of supplemented hormones is not adequately studied in the literature. In most major controlled and randomized studies, there are no significant differences in success rates with progesterone supplementation alone, progesterone and estradiol, progesterone and human chorionic gonadotropin, and human chorionic gonadotropin alone. Success rates seem similar with intramuscular and vaginal progesterone administration with patient preference for the vaginal route. The optimal dose of progesterone has not been studied in a scientific way in the literature. The use of gonadotropin releasing hormone agonists for luteal phase supplementation in antagonist cycles appears to be promising, and is worthy of further investigation. en_US
dc.language.iso en en_US
dc.title Luteal supplementation in in vitro fertilization: more questions than answers en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201600127 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Fertility and Sterility en_US
dc.journal.volume 89 en_US
dc.journal.issue 4 en_US
dc.article.pages 749-758 en_US
dc.identifier.doi https://doi.org/10.1016/j.fertnstert.2008.02.095 en_US
dc.identifier.ctation Hubayter, Z. R., & Muasher, S. J. (2008). Luteal supplementation in in vitro fertilization: more questions than answers. Fertility and sterility, 89(4), 749-758. en_US
dc.author.email ziad.hubayter@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0015028208003622 en_US
dc.author.affiliation Lebanese American University en_US

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