A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiency

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dc.contributor.author Hubayter, Ziad R.
dc.contributor.author Popat, Vaishali
dc.contributor.author Vanderhoof, Vien H.
dc.contributor.author Ndubizu, Obioma
dc.contributor.author Johnson, Diane
dc.contributor.author Mao, Edie
dc.contributor.author Calis, Karim A.
dc.contributor.author Troendle, James F.
dc.contributor.author Nelson, Lawrance M.
dc.date.accessioned 2017-09-05T06:06:01Z
dc.date.available 2017-09-05T06:06:01Z
dc.date.copyright 2010 en_US
dc.date.issued 2017-09-05
dc.identifier.issn 1556-5653 en_US
dc.identifier.uri http://hdl.handle.net/10725/6120
dc.description.abstract Objective To assess ovarian follicle function in women with 46,XX spontaneous primary ovarian insufficiency. Design Case–control with nested prospective cohort. Setting Clinical Research Center, National Institutes of Health. Patient(s) Women with primary ovarian insufficiency without estrogen replacement for 2 weeks (N = 97) and regularly menstruating control women (N = 42). Intervention(s) Single injection of 300 IU hrFSH. Main Outcome Measure(s) Change in serum estradiol at 24 hours. Result(s) Antral follicles ≥3 mm were detected in 73% (69/95) of patients; both serum estradiol and progesterone levels correlated significantly with maximum follicle diameter in these women. Patients with a maximum follicle diameter ≥8 mm had significantly higher serum estradiol and progesterone levels and significantly lower FSH and LH levels compared with patients without such follicles. In controls estradiol levels increased significantly after FSH administration, but in patients this was not the case despite the presence of an antral follicle ≥8 mm. Conclusion(s) Most women with 46,XX spontaneous primary ovarian insufficiency have antral follicles detectable by ultrasound, suggesting that down-regulation of FSH receptors is not the predominant mechanism of follicle dysfunction. Evidence of progesterone secretion by antral follicles ≥8 mm in these patients is consistent with prior histologic evidence that follicle luteinization is the predominant mechanism of follicle dysfunction in this condition. Prospective controlled investigation designed to improve ovulatory function and fertility in these women is indicated. en_US
dc.language.iso en en_US
dc.title A prospective evaluation of antral follicle function in women with 46,XX spontaneous primary ovarian insufficiency en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201600127 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Fertility and Sterility en_US
dc.journal.volume 94 en_US
dc.journal.issue 5 en_US
dc.article.pages 1769-1774 en_US
dc.keywords Primary ovarian insufficiency en_US
dc.keywords hypergonadotropic hypogonadism en_US
dc.keywords Premature ovarian failure en_US
dc.keywords Premature menopause en_US
dc.keywords Lutienized Graafian follicle en_US
dc.identifier.doi https://doi.org/10.1016/j.fertnstert.2009.10.023 en_US
dc.identifier.ctation Hubayter, Z. R., Popat, V., Vanderhoof, V. H., Ndubizu, O., Johnson, D., Mao, E., ... & Nelson, L. M. (2010). A prospective evaluation of antral follicle function in women with 46, XX spontaneous primary ovarian insufficiency. Fertility and sterility, 94(5), 1769-1774. en_US
dc.author.email ziad.hubayter@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0015028209038850 en_US
dc.author.affiliation Lebanese American University en_US

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