Reconstruction and simulation of neocortical microcircuitry

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dc.contributor.author Khazen, Georges
dc.contributor.author Markram, Henry
dc.contributor.author Muller, Eilif
dc.contributor.author Ramaswamy, Srikanth
dc.contributor.author Reimann, Michael W.
dc.contributor.author Abdellah, Marwan
dc.contributor.author Sanchez, Carlos Aguado
dc.date.accessioned 2017-04-25T10:15:22Z
dc.date.available 2017-04-25T10:15:22Z
dc.date.copyright 2015 en_US
dc.date.issued 2017-04-25
dc.identifier.issn 1097-4172 en_US
dc.identifier.uri http://hdl.handle.net/10725/5545
dc.description.abstract We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm3 containing ∼31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ∼8 million connections with ∼37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. en_US
dc.language.iso en en_US
dc.title Reconstruction and simulation of neocortical microcircuitry en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201105253 en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.relation.journal Cell en_US
dc.journal.volume 163 en_US
dc.journal.issue 2 en_US
dc.article.pages 456-492 en_US
dc.identifier.doi http://doi.org/10.1016/j.cell.2015.09.029 en_US
dc.identifier.ctation Markram, H., Muller, E., Ramaswamy, S., Reimann, M. W., Abdellah, M., Sanchez, C. A., ... & Kahou, G. A. A. (2015). Reconstruction and simulation of neocortical microcircuitry. Cell, 163(2), 456-492. en_US
dc.author.email gkhazen@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0092867415011915 en_US
dc.author.affiliation Lebanese American University en_US

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