Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections

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dc.contributor.author Khazen, Georges
dc.contributor.author Tokajian, Sima
dc.contributor.author Ibrahim, Joe
dc.contributor.author Eisen, Jonathan A.
dc.contributor.author Jospin, Guillaume
dc.contributor.author Coil, David A.
dc.date.accessioned 2017-04-25T08:15:42Z
dc.date.available 2017-04-25T08:15:42Z
dc.date.copyright 2016 en_US
dc.identifier.issn 1932-6203 en_US
dc.identifier.uri http://hdl.handle.net/10725/5544
dc.description.abstract Streptococcus pyogenes is a very important human pathogen, commonly associated with skin or throat infections but can also cause life-threatening situations including sepsis, streptococcal toxic shock syndrome, and necrotizing fasciitis. Various studies involving typing and molecular characterization of S. pyogenes have been published to date; however next-generation sequencing (NGS) studies provide a comprehensive collection of an organism’s genetic variation. In this study, the genomes of nine S. pyogenes isolates associated with pharyngitis and skin infection were sequenced and studied for the presence of virulence genes, resistance elements, prophages, genomic recombination, and other genomic features. Additionally, a comparative phylogenetic analysis of the isolates with global clones highlighted their possible evolutionary lineage and their site of infection. The genomes were found to also house a multitude of features including gene regulation systems, virulence factors and antimicrobial resistance mechanisms. en_US
dc.language.iso en en_US
dc.title Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201105253 en_US
dc.author.idnumber 199736770 en_US
dc.author.department Computer Science and Mathematics en_US
dc.description.embargo N/A en_US
dc.relation.journal PLOS One en_US
dc.journal.volume 11.12 en_US
dc.journal.issue 12
dc.article.pages e0168177 en_US
dc.identifier.doi https://doi.org/10.1371/journal.pone.0168177 en_US
dc.identifier.ctation Ibrahim, J., Eisen, J. A., Jospin, G., Coil, D. A., Khazen, G., & Tokajian, S. (2016). Genome Analysis of Streptococcus pyogenes Associated with Pharyngitis and Skin Infections. PloS one, 11(12), e0168177. en_US
dc.author.email gkhazen@lau.edu.lb en_US
dc.author.email stokjian@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168177 en_US
dc.author.affiliation Lebanese American University en_US

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