Dietary protein level alters gentamicin-induced nephrotoxicity in rats

LAUR Repository

Show simple item record

dc.contributor.author Zeeni, N.
dc.contributor.author Selmaoui, B.
dc.contributor.author Beauchamp, D.
dc.contributor.author Labrecque, G.
dc.contributor.author Thibault, L.
dc.date.accessioned 2017-02-28T14:33:20Z
dc.date.available 2017-02-28T14:33:20Z
dc.date.copyright 2007 en_US
dc.date.issued 2017-02-28
dc.identifier.issn 0031-9384 en_US
dc.identifier.uri http://hdl.handle.net/10725/5292
dc.description.abstract Aminoglycosides (AG) such as gentamicin are antimicrobial drugs widely used in the hospital setting due to their efficacy in the treatment of severe gram-negative bacterial infections. However, all AG have the potential to cause nephrotoxicity. Two studies have been conducted (1) to assess the protein level of a diet that would give the best renal outcome with gentamicin administration, and (2) to get a better idea about the rhythms of food ingestion associated with the different protein levels. Adult female Sprague–Dawley rats fully adapted to a standard chow diet, the standard chow with 20% or 55% added casein were chronically treated for 10 days with a nephrotoxic dose of gentamicin sulfate (40 mg/kg/day, i.p.) or a saline solution. Food ingestion patterns of rats were recorded every hour using a Diet Scan system and gentamicin nephrotoxicity indices were measured. The second study used rats that were fed the same diets and given a sham injection. Corticosterone was assayed to quantify the stress of the animals. Results showed that chronic gentamicin treatment leads to a decrease in food intake and flattening of the rhythms of food ingestion. Also, chow feeding and the 20% casein diet were found to be more protective against gentamicin-induced nephrotoxicity than the 55% casein diet. Therefore, while a protein-rich diet can be protective against gentamicin-induced nephrotoxicity, the present study demonstrates that a diet too high in protein might rather be harmful to the kidneys. en_US
dc.language.iso en en_US
dc.title Dietary protein level alters gentamicin-induced nephrotoxicity in rats en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201000400 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Physiology & Behavior en_US
dc.journal.volume 90 en_US
dc.journal.issue 5 en_US
dc.article.pages 760-770 en_US
dc.keywords Gentamicin en_US
dc.keywords Nephrotoxicity en_US
dc.keywords Temporal variation en_US
dc.keywords Food intake en_US
dc.keywords Protein en_US
dc.keywords Rat en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.physbeh.2006.12.018 en_US
dc.identifier.ctation Zeeni, N., Selmaoui, B., Beauchamp, D., Labrecque, G., & Thibault, L. (2007). Dietary protein level alters gentamicin-induced nephrotoxicity in rats. Physiology & behavior, 90(5), 760-770. en_US
dc.author.email nadine.zeeni@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0031938407000042 en_US
dc.orcid.id https://orcid.org/0000-0003-1747-6016 en_US
dc.author.affiliation Lebanese American University en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record

Search LAUR

Advanced Search


My Account