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Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice

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dc.contributor.author Zeeni, N.
dc.contributor.author Nadkam, N.
dc.contributor.author Bell, J.D.
dc.contributor.author Even, P.C.
dc.contributor.author Fromentin, G.
dc.contributor.author Tome, D.
dc.contributor.author Darcel, N.
dc.date.accessioned 2017-02-28T14:26:30Z
dc.date.available 2017-02-28T14:26:30Z
dc.date.copyright 2010 en_US
dc.identifier.issn 1053-8119 en_US
dc.identifier.uri http://hdl.handle.net/10725/5291
dc.description.abstract The aim of this study was to investigate the effect of long-term nutrient intake on the central response to the anorexigenic gut hormone CCK. C57BL/6 mice were fed one of three diets for 6 weeks: standard high carbohydrate (HC), high fat (HF), or high protein (HP). Assessment of brain response to cholecystokinin (CCK) by manganese-enhanced MRI (MEMRI) showed a reduction in neuronal activity both in an appetite-related area (ventromedial nucleus of the hypothalamus) and areas associated with reward (nucleus accumbens and striatum) regardless of diet. When comparing diet effects, while the HF diet did not induce any change in activity, reductions in MEMRI-associated signal were found in the paraventricular nucleus (PVN) and lateral hypothalamic area (LHA) when comparing the HP to the HC diet. In addition, a significant interaction was found between CCK administration and the HF diet, shown by an increased activation in the PVN, which suggests a decrease the inhibiting action of CCK. Our results put forward that the long-term intake of an HP diet leads to a reduction in basal hypothalamic activation while a high-fat diet leads to desensitization to CCK-induced effects in the hypothalamus. en_US
dc.language.iso en en_US
dc.title Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.idnumber 201000400 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal NeuroImage en_US
dc.journal.volume 50 en_US
dc.journal.issue 4 en_US
dc.article.pages 1560-1565 en_US
dc.keywords Manganese-enhanced magnetic resonance imaging (MEMRI) en_US
dc.keywords High-fat diet en_US
dc.keywords High-protein diet en_US
dc.keywords Cholecystokinin en_US
dc.keywords Gut–brain axis en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.neuroimage.2010.01.065 en_US
dc.identifier.ctation Zeeni, N., Nadkarni, N., Bell, J. D., Even, P. C., Fromentin, G., Tome, D., & Darcel, N. (2010). Peripherally injected cholecystokinin-induced neuronal activation is modified by dietary composition in mice. Neuroimage, 50(4), 1560-1565. en_US
dc.author.email nadine.zeeni@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S105381191000087X en_US
dc.author.affiliation Lebanese American University en_US


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