Cyclosporine Lymphocyte Versus Whole Blood Pharmacokinetic Monitoring

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dc.contributor.author Mokhbat, J.
dc.contributor.author Kilani, H.
dc.contributor.author Barbari, A.
dc.contributor.author Masri, M. A.
dc.contributor.author Stephan, A.
dc.contributor.author Rizk, S.
dc.contributor.author Kamel, G.
dc.contributor.author Joubran, N.
dc.date.accessioned 2017-02-27T13:57:46Z
dc.date.available 2017-02-27T13:57:46Z
dc.date.copyright 2001 en_US
dc.date.issued 2017-02-27
dc.identifier.issn 0041-1345 en_US
dc.identifier.uri http://hdl.handle.net/10725/5283
dc.description.abstract Cyclosporine (CyA) blood trough level (BTL), CyA dose pharmacokinetics, area under the curve (AUC), blood Cyclophylin (CyP) binding, and exposure index (EI) are often used as indicators of CyA efficacy and dose adjustment,1; 2 ; 3 despite conflicting results regarding their correlation with graft rejection and CyA nephrotoxicity.4; 5; 6; 7; 8; 9 ; 10 CyA immunosuppressive effect is initiated by its binding to its lymphocyte (Lc) receptor, the CyP.11 ; 12 It would be, therefore, more advantageous to monitor CyA pharmacokinetics at the site of action with the Lc by measuring intra-lymphocytic CyA trough level (LTL). Recent studies have shown a good correlation between CyA-CyP binding and its in vitro immunosuppressive activity. 13 ; 14 We hypothesized that drug-receptor interaction measurement might reflect more accurately the concentrations of biologically relevant compounds and hence may provide a better correlation with clinical events. The aim of our study was to compare CyA LTL to CyA BTL and dose in relation to 1) histological findings in renal transplant patients with graft dysfunction and 2) total lymphocyte count, a reflector of the state of immunosuppression. en_US
dc.language.iso en en_US
dc.title Cyclosporine Lymphocyte Versus Whole Blood Pharmacokinetic Monitoring en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle Correlation With Histological Findings en_US
dc.author.school SOM en_US
dc.author.idnumber 200902719 en_US
dc.author.idnumber 201004806 en_US
dc.author.idnumber 199829370 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Transplantation Proceedings en_US
dc.journal.volume 33 en_US
dc.journal.issue 5 en_US
dc.article.pages 2782–2785 en_US
dc.identifier.doi http://dx.doi.org/10.1016/S0041-1345(01)02190-X en_US
dc.identifier.ctation Barbari, A., Masri, M. A., Stephan, A., Mokhbat, J., Kilani, H., Rizk, S., ... & Joubran, N. (2001, August). Cyclosporine lymphocyte versus whole blood pharmacokinetic monitoring: correlation with histological findings. In Transplantation proceedings 33(5), 2782-2785 en_US
dc.author.email jacques.mokhbat@lau.edu.lb en_US
dc.author.email hala.kilani@lau.edu.lb en_US
dc.author.email sandra.rizk@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://ku7rj9xt8c.scholar.serialssolutions.com/?sid=google&auinit=A&aulast=Barbari&atitle=Cyclosporine+lymphocyte+versus+whole+blood+pharmacokinetic+monitoring:+correlation+with+histological+findings.&id=pmid:11498159 en_US
dc.orcid.id https://orcid.org/0000-0002-4405-5703 en_US
dc.author.affiliation Lebanese American University en_US

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