Phosphorus supplementation recovers the blunted diet-induced thermogenesis of overweight and obese adults

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dc.contributor.author Bassil, Maya S.
dc.contributor.author Obeid, Omar A.
dc.date.accessioned 2017-02-23T11:47:33Z
dc.date.available 2017-02-23T11:47:33Z
dc.date.copyright 2016 en_US
dc.date.issued 2017-02-23
dc.identifier.issn 2072-6643 en_US
dc.identifier.uri http://hdl.handle.net/10725/5272
dc.description.abstract Diet-induced thermogenesis (DIT) is believed to be largely related to ATP production, which is dependent on phosphorus (P) availability. We aimed to test the effect of P addition on DIT of lean and overweight/obese healthy subjects. DIT was measured with or without P in 10 lean and 13 overweight/obese adults in a double-blind randomized cross-over pilot study with one week washout period. After 10 h overnight fast, resting metabolic rate, respiratory quotient, and substrate utilization were measured at fasting and every 30 min for 3 h after subjects drank a standardized glucose solution, with P (500 mg) or placebo pills. Subjective ratings of hunger and satiety were assessed before and after the end of each experiment using validated visual analogue scale (VAS) questionnaires. Overweight/obese subjects had a blunted DIT with placebo, while P supplementation induced a 23% increase in their DIT area under the curve (p < 0.05), which was associated with a significant increase in carbohydrate oxidation. Subjects had lower appetite following P supplementation, which was expressed as a significantly (p = 0.02) lower desire to eat a meal (4.0 ± 0.7 cm) compared with placebo (5.8 ± 0.9 cm). P supplementation recovers the blunted diet-induced thermogenesis in overweight and obese subjects and enhances their postprandial satiety. en_US
dc.language.iso en en_US
dc.title Phosphorus supplementation recovers the blunted diet-induced thermogenesis of overweight and obese adults en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a pilot study en_US
dc.author.school SAS en_US
dc.author.idnumber 201102356 en_US
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Nutrients en_US
dc.journal.volume 8 en_US
dc.journal.issue 12 en_US
dc.article.pages 801 en_US
dc.keywords Phosphorus en_US
dc.keywords Supplementation en_US
dc.keywords Diet induced thermogenesis en_US
dc.keywords Obesity en_US
dc.keywords Energy expenditure en_US
dc.keywords Energy balance en_US
dc.identifier.doi http://dx.doi.org/10.3390/nu8120801 en_US
dc.identifier.ctation Bassil, M. S., & Obeid, O. A. (2016). Phosphorus Supplementation Recovers the Blunted Diet-Induced Thermogenesis of Overweight and Obese Adults: A Pilot Study. Nutrients, 8(12), 801. en_US
dc.author.email mbassil@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.mdpi.com/2072-6643/8/12/801/htm en_US
dc.author.affiliation Lebanese American University en_US

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