Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation

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dc.contributor.author Mokhbat, J. E.
dc.contributor.author Greenman, R. L.
dc.contributor.author Arcey, S. M.
dc.contributor.author Dickinson, G. M.
dc.contributor.author Sabath, L. D.
dc.contributor.author Platt, T. B.
dc.contributor.author Friedhoff, L. T.
dc.date.accessioned 2017-02-15T15:18:43Z
dc.date.available 2017-02-15T15:18:43Z
dc.date.copyright 1985 en_US
dc.identifier.issn 0305-7453 en_US
dc.identifier.uri http://hdl.handle.net/10725/5239
dc.description.abstract Cerebrospinal fluid of aztreonam were measured in 11 patients with meningeal inflammation. Two to eight hours after a single 2 gin intravenous dose, CSF aztreonam levels ranged from 0·76 to 16·6 mg/l. The mean CSF concentration in four patients with viral meningitis was 1·28 mg/l, which was lower than the mean con centration of 7·2 mg/l in the five with bacterial, cryptococcal or carcinomatous meningitis. Two patients with infected subdural drains were also sampled serially and had CSF levels greater than 1 mg/l between 1 and 8 h post dose. Penetration of aztreonam into the CSF in the presence of meningeal inflammation appears adequate to warrant therapeutic trials in patients infected with susceptible organisms. en_US
dc.language.iso en en_US
dc.title Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902719 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Antimicrobial Chemotherapy en_US
dc.journal.volume 15 en_US
dc.journal.issue 5 en_US
dc.keywords Inflammation en_US
dc.keywords Aztreonam en_US
dc.keywords Viral meningitis en_US
dc.keywords Subdural space en_US
dc.keywords Cerebrospinal fluid en_US
dc.keywords Cryptococcus en_US
dc.keywords Drainage procedure en_US
dc.keywords Carcinomatous meningitis en_US
dc.identifier.doi https://doi.org/10.1093/jac/15.5.637 en_US
dc.identifier.ctation Greenman, R. L., Arcey, S. M., Dickinson, G. M., Mokhbat, J. E., Sabath, L. D., Platt, T. B., & Friedhoff, L. T. (1985). Penetration of aztreonam into human cerebrospinal fluid in the presence of meningeal inflammation. Journal of Antimicrobial Chemotherapy, 15(5), 637-640. en_US
dc.author.email jacques.mokhbat@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://academic.oup.com/jac/article-abstract/15/5/637/742754/Penetration-of-aztreonam-into-human-cerebrospinal en_US
dc.author.affiliation Lebanese American University en_US

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