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Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients

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dc.contributor.author Mokhbat, J.
dc.contributor.author Irani-Hakime, N.
dc.contributor.author Samaha, H.
dc.contributor.author Almawi, W.
dc.contributor.author Abou Jaoude, M.
dc.contributor.author Daccache, J.
dc.contributor.author Rahal, E.
dc.date.accessioned 2017-02-15T14:08:21Z
dc.date.available 2017-02-15T14:08:21Z
dc.date.copyright 2003 en_US
dc.identifier.issn 0023-9852 en_US
dc.identifier.uri http://hdl.handle.net/10725/5231
dc.description.abstract To assess percentages of hepatitis C virus (HCV) genotypes in infected Lebanese patients referred to St. George Hospital, Beirut, Lebanon, 77 infected cases were studied. Of those, 27 were hemodialysis patients. Genotyping was performed by nested PCR of the HCV core-region with specific primers, followed by DNA enzyme-immunoassay using HCV type and subtype-specific probes. Single genotype infections were detected in 52 patients (67.5%). In these cases, types 1, 2, 3 and 4 were detected in 19.5%, 32.5%, 5.1% and 10.4% of the cases respectively. Twenty-five (32.5%) samples showed mixed genotype infections. Single genotype distribution was significantly different among dialysis and non-dialysis patients. In the dialysis group, genotype 2 was predominant (80%, p < 0.001). In single HCV genotype-infected patients, subtype 1b was frequently detected in nondialysis cases (34.4%) whereas this genotype was found in only 5% of dialysis cases. Genotypes 5 and 6 were not detected in any of the cases studied. This pilot hospital-based study provides evidence for the diversity of HCV genotypes in the Lebanese population and establishes differences in distribution depending on the risk group. en_US
dc.language.iso en en_US
dc.title Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a hospital-based study en_US
dc.author.school SOM en_US
dc.author.idnumber 200902719 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Lebanese Medical Journal en_US
dc.journal.volume 51 en_US
dc.journal.issue 3 en_US
dc.article.pages 121-126 en_US
dc.identifier.ctation Irani-Hakime, N., Samaha, H., Almawi, W., Nasr, E., Mokhbat, J., Abou, J. M., ... & Rahal, E. (2002). Prevalence of hepatitis C virus isolate genotypes from chronically infected Lebanese patients: a hospital-based study. Le Journal medical libanais. The Lebanese medical journal, 51(3), 121-126. en_US
dc.author.email jacques.mokhbat@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://europepmc.org/abstract/med/15707071 en_US
dc.author.affiliation Lebanese American University en_US


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