Penicillin-resistant streptococcus pneumoniae in Lebanon

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dc.contributor.author Mokhbat, Jacques E.
dc.contributor.author Uwaydah, Marwan
dc.contributor.author Karam-Sarkis, Dolla
dc.contributor.author Baroud-Nassif, Rita
dc.contributor.author Rohban, Thomas
dc.date.accessioned 2017-02-10T08:44:06Z
dc.date.available 2017-02-10T08:44:06Z
dc.date.copyright 2006 en_US
dc.date.issued 2017-02-10
dc.identifier.issn 0924-8579 en_US
dc.identifier.uri http://hdl.handle.net/10725/5205
dc.description.abstract A total of 123 clinical isolates of Streptococcus pneumoniae were collected from all over Lebanon and tested for their susceptibility to penicillin: 30.1% were susceptible (minimum inhibitory concentration (MIC) ≤ 0.06 μg/mL), 56.1% were intermediately susceptible (MIC 0.09–1.0 μg/mL) and 13.8% were resistant (MIC > 1.0 μg/mL). The oxacillin disk screening test detected all penicillin-resistant isolates, but erroneously designated two penicillin-intermediate isolates as penicillin susceptible. All isolates were consistently susceptible to levofloxacin, but cross-resistance between penicillin and the three tested cephalosporins was frequently noted. The in vitro activity of amoxicillin/clavulanic acid paralleled that of penicillin; however, 92.7% of the isolates were designated as susceptible based on the recommended interpretive cut-off point (MIC ≤ 2/1 μg/mL). This discrepancy represents a paradox that deserves serious consideration. en_US
dc.language.iso en en_US
dc.title Penicillin-resistant streptococcus pneumoniae in Lebanon en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle the first nationwide study en_US
dc.author.school SOM en_US
dc.author.idnumber 200902719 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Antimicrobial Agents en_US
dc.journal.volume 27 en_US
dc.journal.issue 3 en_US
dc.article.pages 242-246 en_US
dc.keywords Streptococcus pneumoniae en_US
dc.keywords Penicillin non-susceptible en_US
dc.keywords Oxacillin screening test en_US
dc.keywords Levofloxacin en_US
dc.keywords Lebanon en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.ijantimicag.2005.10.019 en_US
dc.identifier.ctation Uwaydah, M., Mokhbat, J. E., Karam-Sarkis, D., Baroud-Nassif, R., & Rohban, T. (2006). Penicillin-resistant Streptococcus pneumoniae in Lebanon: the first nationwide study. International journal of antimicrobial agents, 27(3), 242-246. en_US
dc.author.email jacques.mokhbat@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0924857905003547 en_US
dc.author.affiliation Lebanese American University en_US

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