dc.contributor.author |
Mokhbat, Jacques E. |
|
dc.contributor.author |
Uwaydah, Marwan |
|
dc.contributor.author |
Karam-Sarkis, Dolla |
|
dc.contributor.author |
Baroud-Nassif, Rita |
|
dc.contributor.author |
Rohban, Thomas |
|
dc.date.accessioned |
2017-02-10T08:44:06Z |
|
dc.date.available |
2017-02-10T08:44:06Z |
|
dc.date.copyright |
2006 |
en_US |
dc.date.issued |
2017-02-10 |
|
dc.identifier.issn |
0924-8579 |
en_US |
dc.identifier.uri |
http://hdl.handle.net/10725/5205 |
|
dc.description.abstract |
A total of 123 clinical isolates of Streptococcus pneumoniae were collected from all over Lebanon and tested for their susceptibility to penicillin: 30.1% were susceptible (minimum inhibitory concentration (MIC) ≤ 0.06 μg/mL), 56.1% were intermediately susceptible (MIC 0.09–1.0 μg/mL) and 13.8% were resistant (MIC > 1.0 μg/mL). The oxacillin disk screening test detected all penicillin-resistant isolates, but erroneously designated two penicillin-intermediate isolates as penicillin susceptible. All isolates were consistently susceptible to levofloxacin, but cross-resistance between penicillin and the three tested cephalosporins was frequently noted. The in vitro activity of amoxicillin/clavulanic acid paralleled that of penicillin; however, 92.7% of the isolates were designated as susceptible based on the recommended interpretive cut-off point (MIC ≤ 2/1 μg/mL). This discrepancy represents a paradox that deserves serious consideration. |
en_US |
dc.language.iso |
en |
en_US |
dc.title |
Penicillin-resistant streptococcus pneumoniae in Lebanon |
en_US |
dc.type |
Article |
en_US |
dc.description.version |
Published |
en_US |
dc.title.subtitle |
the first nationwide study |
en_US |
dc.author.school |
SOM |
en_US |
dc.author.idnumber |
200902719 |
en_US |
dc.author.department |
N/A |
en_US |
dc.description.embargo |
N/A |
en_US |
dc.relation.journal |
International Journal of Antimicrobial Agents |
en_US |
dc.journal.volume |
27 |
en_US |
dc.journal.issue |
3 |
en_US |
dc.article.pages |
242-246 |
en_US |
dc.keywords |
Streptococcus pneumoniae |
en_US |
dc.keywords |
Penicillin non-susceptible |
en_US |
dc.keywords |
Oxacillin screening test |
en_US |
dc.keywords |
Levofloxacin |
en_US |
dc.keywords |
Lebanon |
en_US |
dc.identifier.doi |
http://dx.doi.org/10.1016/j.ijantimicag.2005.10.019 |
en_US |
dc.identifier.ctation |
Uwaydah, M., Mokhbat, J. E., Karam-Sarkis, D., Baroud-Nassif, R., & Rohban, T. (2006). Penicillin-resistant Streptococcus pneumoniae in Lebanon: the first nationwide study. International journal of antimicrobial agents, 27(3), 242-246. |
en_US |
dc.author.email |
jacques.mokhbat@lau.edu.lb |
en_US |
dc.identifier.tou |
http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php |
en_US |
dc.identifier.url |
http://www.sciencedirect.com/science/article/pii/S0924857905003547 |
en_US |
dc.author.affiliation |
Lebanese American University |
en_US |