Countrywide Spread of Community- and Hospital-Acquired Extended-Spectrum β-Lactamase (CTX-M-15)-Producing Enterobacteriaceae in Lebanon

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dc.contributor.author Mokhbat, Jacques E.
dc.contributor.author Moubareck, Carole
dc.contributor.author Daoud, Ziad
dc.contributor.author Hakime, Noha I.
dc.contributor.author Hamze, Monzer
dc.contributor.author Mangeney, Nicole
dc.contributor.author Matta, Hiam
dc.contributor.author Rohban, Raymond
dc.contributor.author Karam-Sarkis, Dolla
dc.contributor.author Doucet-Populaire, Florence
dc.date.accessioned 2017-02-10T07:50:57Z
dc.date.available 2017-02-10T07:50:57Z
dc.date.copyright 2005 en_US
dc.date.issued 2017-02-10
dc.identifier.issn 0095-1137 en_US
dc.identifier.uri http://hdl.handle.net/10725/5202
dc.description.abstract A prospective study was carried out to assess the extent of carriage of extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae at both hospital and community levels in Lebanon. A total of 1,442 fecal samples were collected from hospital-based patients and 58 from health care workers of six Lebanese tertiary care general hospitals located in different areas of Lebanon between January and March 2003. A total of 382 fecal samples were also collected from healthy subjects between April and June 2003. The samples analysis led to the identification of 118 strains as ESBL producers based on the synergistic effects between clavulanate and selected β-lactams (ceftazidime and cefotaxime). These strains were isolated from 72 subjects: 61 patients, 2 health care workers, and 9 healthy subjects. One representative strain per subject was selected, and a total of 72 nonduplicate ESBL producers, including a high majority of Escherichia coli (n = 56), Klebsiella pneumoniae (n = 9), Enterobacter cloacae (n = 6), and Citrobacter freundii (n = 1), were characterized. The molecular analysis revealed that the majority of the strains (83%) express CTX-M-15 ESBL (pI 8.6). SHV-5a ESBL (pI 8.2) was produced by 18% of the strains. DNA macrorestriction analysis of ESBL-producing E. coli presented 38 different genotypes, revealing the absence of clonal link among these strains. In addition to the fact that the present study highlights the emergence and the countrywide dissemination of CTX-M-15-producing E. coli in Lebanon, it represents the first report of an SHV-5a-producing C. freundii. en_US
dc.language.iso en en_US
dc.title Countrywide Spread of Community- and Hospital-Acquired Extended-Spectrum β-Lactamase (CTX-M-15)-Producing Enterobacteriaceae in Lebanon en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902719 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Clinical Microbiology en_US
dc.journal.volume 43 en_US
dc.journal.issue 7 en_US
dc.article.pages 3309-3313 en_US
dc.identifier.doi http://dx.doi.org/10.1128/JCM.43.7.3309-3313.2005 en_US
dc.identifier.ctation Moubareck, C., Daoud, Z., Hakimé, N. I., Hamzé, M., Mangeney, N., Matta, H., ... & Doucet-Populaire, F. (2005). Countrywide spread of community-and hospital-acquired extended-spectrum β-lactamase (CTX-M-15)-producing Enterobacteriaceae in Lebanon. Journal of clinical microbiology, 43(7), 3309-3313. en_US
dc.author.email jacques.mokhbat@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://jcm.asm.org/content/43/7/3309.full.pdf+html en_US
dc.author.affiliation Lebanese American University en_US

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