Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells

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dc.contributor.author Zgheib, Perla
dc.contributor.author Daher, Costantine F.
dc.contributor.author Mroueh, Mohamad
dc.contributor.author Nasrallah, Anita
dc.contributor.author Taleb, Robin I.
dc.contributor.author El-Sibai, Mirvat
dc.date.accessioned 2017-02-08T12:30:01Z
dc.date.available 2017-02-08T12:30:01Z
dc.date.copyright 2015 en_US
dc.date.issued 2017-02-08
dc.identifier.issn 0009-3157 en_US
dc.identifier.uri http://hdl.handle.net/10725/5196
dc.description.abstract Daucus carota (DC) is a herb used in folklore medicine in Lebanon to treat numerous diseases including cancer. Recent studies in our laboratory on DC oil and its fractions revealed potent anticancer activities in vitro and in vivo. The present study aims to investigate the effect of the most potent DC fraction, pentane/diethyl ether (50:50), on lung, skin, breast and glioblastoma cancer cell motility and invasion. Upon treatment, a pronounced decrease in cancer cell motility was observed in the 4 cell lines. The treatment also led to a decrease in cancer cell invasion and an increased cell adhesion. Additionally, the DC fraction caused a decrease in the activation of the ρ-GTPases Rac and CDC42, a finding that may partially explain the treatment-induced decrease in cell motility. The current study demonstrates a crucial effect of the DC pentane/diethyl ether fraction on cancer cell motility and metastasis, making it a potential candidate for cancer therapy specifically targeting cancer motility and metastasis. en_US
dc.language.iso en en_US
dc.title Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SAS en_US
dc.author.school SOP
dc.author.idnumber 199190130 en_US
dc.author.idnumber 199590020
dc.author.idnumber 200901968
dc.author.idnumber 200703859
dc.author.department Natural Sciences en_US
dc.description.embargo N/A en_US
dc.relation.journal Chemotherapy en_US
dc.journal.volume 60 en_US
dc.journal.issue 5-6 en_US
dc.article.pages 302-309 en_US
dc.keywords Daucus carota en_US
dc.keywords Cancer en_US
dc.keywords Metastasis en_US
dc.keywords Motility en_US
dc.keywords ρ-GTPases en_US
dc.identifier.doi http://dx.doi.org/10.1159/000430085 en_US
dc.identifier.ctation Zgheib, P., Daher, C. F., Mroueh, M., Nasrallah, A., Taleb, R. I., & El-Sibai, M. (2015). Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells. Chemotherapy, 60(5-6), 302-309. en_US
dc.author.email cdaher@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb
dc.author.email robin.taleb@lau.edu.lb
dc.author.email mirvat.elsibai@lau.edu.lb
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.karger.com/Article/Abstract/430085 en_US
dc.orcid.id https://orcid.org/0000-0003-4084-6759 en_US
dc.author.affiliation Lebanese American University en_US

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