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The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy in Saccharomyces cerevisiae

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dc.contributor.author Stephan, Joseph S.
dc.contributor.author Yeh, Yuh-Ying
dc.contributor.author Vidhya Ramachandran, Vidhya
dc.contributor.author Deminoff, Stephen J.
dc.contributor.author Herman, Paul K.
dc.date.accessioned 2017-02-06T12:05:45Z
dc.date.available 2017-02-06T12:05:45Z
dc.date.copyright 2010 en_US
dc.identifier.issn 1554-8627 en_US
dc.identifier.uri http://hdl.handle.net/10725/5187
dc.description.abstract Macroautophagy (hereafter autophagy) is a conserved membrane trafficking pathway responsible for the turnover of cytosolic protein and organelles during periods of nutrient deprivation. This pathway is also linked to a number of processes important for human health, including tumor suppression, innate immunity and the clearance of protein aggregates. As a result, there is tremendous interest in autophagy as a potential point of therapeutic intervention in a variety of pathological states. To achieve this goal, it is imperative that we develop a thorough understanding of the normal regulation of this process in eukaryotic cells. The Tor protein kinases clearly constitute a key element of this control as Tor activity inhibits this degradative process in all organisms examined, from yeast to man. Here, we discuss recent work indicating that the cAMP-dependent protein kinase (PKA) also plays a critical role in controlling autophagy in the budding yeast, Saccharomyces cerevisiae. A model describing how PKA activity might influence this degradative process, and how this control might be integrated with that of the Tor pathway, is presented. en_US
dc.language.iso en en_US
dc.title The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy in Saccharomyces cerevisiae en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201509224 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Autophagy en_US
dc.journal.volume 6 en_US
dc.journal.issue 2 en_US
dc.article.pages 294-295 en_US
dc.keywords Atg1 en_US
dc.keywords Macroautophagy en_US
dc.keywords Phagophore assembly structure en_US
dc.keywords Atg13 en_US
dc.keywords Nutritional control en_US
dc.identifier.doi http://dx.doi.org/10.4161/auto.6.2.11129 en_US
dc.identifier.ctation Stephan, J. S., Yeh, Y. Y., Vidhya Ramachandran, V., Deminoff, S. J., & Herman, P. K. (2010). The Tor and cAMP-dependent protein kinase signaling pathways coordinately control autophagy in Saccharomyces cerevisiae. Autophagy, 6(2), 294-295. en_US
dc.author.email joseph.stephan@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.tandfonline.com/doi/abs/10.4161/auto.6.2.11129 en_US
dc.author.affiliation Lebanese American University en_US


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