Phenol sulfotransferases

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dc.contributor.author Nasser, Selim M.
dc.contributor.author Seth, Pankaj
dc.contributor.author Lunetta, Kathryn L.
dc.contributor.author Bell, Daphne W.
dc.contributor.author Gray, Heather
dc.contributor.author Rhei, Esther
dc.contributor.author Kaelin, Carolyn M.
dc.contributor.author Iglehart, Dirk J.
dc.contributor.author Marks, Jeffrey R.
dc.contributor.author Garber, Judy E.
dc.contributor.author Haber, Daniel A.
dc.contributor.author Polyak, Kornelia
dc.date.accessioned 2017-02-03T10:38:50Z
dc.date.available 2017-02-03T10:38:50Z
dc.date.copyright 2000 en_US
dc.date.issued 2017-02-03
dc.identifier.issn 0008-5472 en_US
dc.identifier.uri http://hdl.handle.net/10725/5170
dc.description.abstract In recent years, significant effort has been made to identify genes that influence breast cancer risk. Because the high-penetrance breast cancer susceptibility genes BRCA1 and 2 play a role only in a small fraction of breast cancer cases, understanding the genetic risk of the majority of breast cancers will require the identification and analysis of several lower penetrance genes. The estrogen-signaling pathway plays a crucial role in the pathophysiology of breast cancer; therefore, polymorphism in genes involved in this pathway is likely to influence breast cancer risk. Our detailed analysis of gene expression profiles of estrogen- and 4-OH-tamoxifen-treated ZR75-1 breast cancer cells identified members of the sulfotransferase 1A (SULT1A) phenol sulfotransferase family as downstream targets of tamoxifen. On the basis of the induction of SULT1A by 4-OH-tamoxifen and the known inherited variability in SULT1A enzymatic activity, we hypothesized that polymorphism in sulfotransferase genes might influence the risk of breast cancer. Using an RFLP that distinguishes an arginine to histidine change in exon 7 of the SULT1A1 gene, we characterized SULT1A1 genotypes in relation to breast cancer risk. An analysis of 444 breast cancer patients and 227 controls revealed no effect of SULT1A1 genotype on the risk of breast cancer (P = 0.69); however, it did appear to influence the age of onset among early-onset affected patients (P = 0.04). Moreover, individuals with the higher activity SULT1A1*1 allele were more likely to have other tumors in addition to breast cancer (P = 0.004; odds ratio, 3.02; 95% confidence interval, 1.32, 8.09). The large number of environmental mutagens and carcinogens activated by sulfotransferases and the high frequency of the SULT1A1*1 allele in human populations warrants additional studies to address the role of SULT genes in human cancer. en_US
dc.language.iso en en_US
dc.title Phenol sulfotransferases en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle hormonal regulation, polymorphism, and age of onset of breast cancer en_US
dc.author.school SOM en_US
dc.author.idnumber 200804624 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Cancer Research en_US
dc.journal.volume 60 en_US
dc.journal.issue 24 en_US
dc.article.pages 6859-6863 en_US
dc.identifier.ctation Seth, P., Lunetta, K. L., Bell, D. W., Gray, H., Nasser, S. M., Rhei, E., ... & Haber, D. A. (2000). Phenol sulfotransferases: hormonal regulation, polymorphism, and age of onset of breast cancer. Cancer Research, 60(24), 6859-6863. en_US
dc.author.email selim.nasser@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://cancerres.aacrjournals.org/content/60/24/6859.short en_US
dc.author.affiliation Lebanese American University en_US

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