LYVE-1 is not restricted to the lymph vessels

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dc.contributor.author Nasser, Selim M.
dc.contributor.author Carreira, Carla Mouta
dc.contributor.author Di Timaso, Emmanuelle
dc.contributor.author Padera, Timothy P.
dc.contributor.author Boucher, Yves
dc.contributor.author Tomarev, Stanislav I.
dc.contributor.author Jain, Rakesh K.
dc.date.accessioned 2017-02-02T12:03:26Z
dc.date.available 2017-02-02T12:03:26Z
dc.date.copyright 2001 en_US
dc.date.issued 2017-02-02
dc.identifier.issn 0008-5472 en_US
dc.identifier.uri http://hdl.handle.net/10725/5162
dc.description.abstract Lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 is thought to be restricted to lymph vessels and has been used as such to show that tumor lymphangiogenesis occurs on overexpression of lymphangiogenic factors in mouse tumor models. However, these studies have not yet been corroborated in human tumors. Here we show, first, that LYVE-1 is not exclusive to the lymph vessels. Indeed, LYVE-1 is also present in normal hepatic blood sinusoidal endothelial cells in mice and humans. Surprisingly, LYVE-1 is absent from the angiogenic blood vessels of human liver tumors and only weakly present in the microcirculation of regenerative hepatic nodules in cirrhosis, though both vessels are largely derived from the liver sinusoids. Second, we propose a novel approach to identify lymphatics in human and murine liver. By combining LYVE-1 and Prox 1 (a transcription factor) immunohistochemistry, we demonstrate that lymphatics are abundant in cirrhosis. In contrast, in human hepatocellular carcinoma and liver metastases, they are restricted to the tumor margin and surrounding liver. The absence of intratumor lymphatics in hepatocellular carcinomas and liver metastases may impair molecular and cellular transport in these tumors. Finally, the presence of LYVE-1 in liver sinusoidal endothelia suggests that LYVE-1 has functions beyond the lymph vascular system. en_US
dc.language.iso en en_US
dc.title LYVE-1 is not restricted to the lymph vessels en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200804624 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Cancer Research en_US
dc.journal.volume 61 en_US
dc.journal.issue 22 en_US
dc.article.pages 8079-8084 en_US
dc.identifier.ctation Carreira, C. M., Nasser, S. M., di Tomaso, E., Padera, T. P., Boucher, Y., Tomarev, S. I., & Jain, R. K. (2001). LYVE-1 is not restricted to the lymph vessels. Cancer research, 61(22), 8079-8084. en_US
dc.author.email selim.nasser@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://cancerres.aacrjournals.org/content/61/22/8079.short en_US
dc.author.affiliation Lebanese American University en_US

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