Expression of androgen, estrogen, and progesterone receptors in salivary gland tumors

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dc.contributor.author Nasser, Selim M.
dc.contributor.author Faquin, William C.
dc.contributor.author Dayal, Yogeshwar
dc.date.accessioned 2017-02-02T10:32:29Z
dc.date.available 2017-02-02T10:32:29Z
dc.date.copyright 2015 en_US
dc.date.issued 2017-02-02
dc.identifier.issn 0002-9173 en_US
dc.identifier.uri http://hdl.handle.net/10725/5159
dc.description.abstract The expression of sex hormone receptors in some tumors suggests a role for these receptors in tumor pathogenesis and therapy. Previous studies of the expression of estrogen and progesterone receptors in salivary gland tumors have reported conflicting results. We evaluated the immunohistochemical expression of androgen, estrogen, and progesterone receptors (AR, ER, and PR) in a series of 78 formalin-fixed, paraffin-embedded salivary gland tumors. Immunoreactivity for AR was seen in 14 of 14 carcinoma ex pleomorphic adenomas, 6 of 6 salivary duct carcinomas, and 2 of 2 basal cell adenocarcinomas but in only 2 of 10 acinic cell carcinomas, mucoepidermoid carcinomas, and adenoid cystic carcinomas each. AR expression was distributed evenly between the sexes. ER and PR were expressed in only a few cases of salivary gland tumors. All 26 benign salivary gland tumors were negative for AR, ER, and PR. The uniform expression of AR exclusively in a subset of malignant salivary gland tumors suggests a possible role for AR in the histogenesis and possibly in the clinical management of these malignant salivary gland tumors. en_US
dc.language.iso en en_US
dc.title Expression of androgen, estrogen, and progesterone receptors in salivary gland tumors en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle frequent expression of androgen receptor in a subset of malignant salivary gland tumors en_US
dc.author.school SOM en_US
dc.author.idnumber 200804624 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Clinical Pathology en_US
dc.journal.volume 119 en_US
dc.journal.issue 6 en_US
dc.article.pages 801-806 en_US
dc.keywords Salivary gland en_US
dc.keywords Androgen en_US
dc.keywords Progesterone en_US
dc.keywords Estrogen en_US
dc.keywords Receptors en_US
dc.keywords Hormones en_US
dc.identifier.doi http://dx.doi.org/10.1309/RVTP1G0Q727WJUQD en_US
dc.identifier.ctation Nasser, S. M., Faquin, W. C., & Dayal, Y. (2003). Expression of androgen, estrogen, and progesterone receptors in salivary gland tumors. American journal of clinical pathology, 119(6), 801-806. en_US
dc.author.email selim.nasser@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://academic.oup.com/ajcp/article/119/6/801/1758717/Expression-of-Androgen-Estrogen-and-Progesterone en_US
dc.author.affiliation Lebanese American University en_US

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