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Fox–Fordyce Disease

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dc.contributor.author Nasser, S.
dc.contributor.author Sammour, R.
dc.contributor.author Dehaby, N.
dc.contributor.author El Habr, C.
dc.date.accessioned 2017-02-02T08:56:42Z
dc.date.available 2017-02-02T08:56:42Z
dc.date.copyright 2016 en_US
dc.identifier.issn 0926-9959 en_US
dc.identifier.uri http://hdl.handle.net/10725/5151
dc.description.abstract Background Fox–Fordyce Disease (FFD) is a rare chronic inflammatory skin disease of the apocrine glands, mainly affecting post-pubertal women. It involves apocrine gland-bearing areas including the axilla, areola, anogenital area and umbilicus. FFD induced by laser hair removal is a newly reported entity of unknown pathogenesis. To the best of our knowledge, there are only four reported cases in the literature describing a total of four patients. Objectives We are reporting the first case series of laser-induced FFD with a histopathological and clinical evaluation of the reported cases. Methods A review of the available literature to date about laser-induced FFD was performed. Clinical and histopathological features were reviewed. Results In our case series, the clinical and histological appearance of FFD following laser hair removal is similar to that of classic FFD. Exacerbating factors were present in two patients, and were similar to that of classic FFD. The main histopathological features included dilatation of the follicular infundibulum, follicular hyperkeratosis, dyskeratosis in the follicular infundibulum, periductal lymphohistiocytic infiltrate and perifollicular fibrosis. Two of the four reported cases as well as one of our patients had no perifollicular xanthomatous inflammation, a hallmark feature of classic FFD. Mast cells were absent in all reported cases, as well as in our patients. Conclusion: We believe that laser-induced FFD is under-diagnosed as a newly reported adverse event of laser hair removal. It is clinically and histopathologically similar to classic FFD. en_US
dc.language.iso en en_US
dc.title Fox–Fordyce Disease en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle an under-diagnosed adverse event of laser hair removal? en_US
dc.author.school SOM en_US
dc.author.idnumber 200804624 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of the European Academy of Dermatology and Venereology en_US
dc.journal.volume 30 en_US
dc.journal.issue 9 en_US
dc.article.pages 1578-1582 en_US
dc.identifier.doi http://dx.doi.org/10.1111/jdv.13680 en_US
dc.identifier.ctation Sammour, R., Nasser, S., Debahy, N., & El Habr, C. (2016). Fox–Fordyce Disease: An under‐diagnosed adverse event of laser hair removal?. Journal of the European Academy of Dermatology and Venereology, 30(9), 1578-1582. en_US
dc.author.email selim.nasser@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1111/jdv.13680/full en_US
dc.author.affiliation Lebanese American University en_US


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