Coronary artery disease. (c2011)

Abstract

Coronary Artery Disease (CAD) is a multifactorial disease with acquired and inherited components. This study aim was to evaluate the function of MPO in discriminating angiographic CAD result, to demonstrate the role of SNPs 599839-12487736 in early onset of CAD and to isolate the role of genetics by exploring the concomitant effect of consanguinity and disease family history in determining risk and age at diagnosis of CAD. CAD was determined by cardiac catheterization. Analysis of variance, chi square, spearman’s correlation, Gensini score and logistic regression tests were constructed to isolate genetic and environmental impacts of family history, to determine the genetic impact on disease expression and age at diagnosis of CAD, and to clarify the role of MPO in stenosis severity. Family history of CAD and age showed significant risk for young age at diagnosis of CAD (p <0.001).Consanguinity did not appear to promote risk of CAD (p =0.375 category 3), but rather significantly associated with young age of disease diagnosis (p <0.001).MPO levels were not statistically correlated with Gensini scores. Only rs599389 was significantly associated with the early onset of CAD. The minor allele G of rs599389 is a protector for early onset of CAD while family history of CAD is a strong promoter of young age at diagnosis. Furthermore, parental consanguinity in the presence of family history lowers the age of disease diagnosis significantly for CAD, emphasizing the role of strong genetic CAD modifiers. These results place the age of disease diagnosis as an important screening factor in genetic disease association studies.