Abstract:
Coronary Artery Disease (CAD) is a multifactorial disease with acquired and
inherited components. This study aim was to evaluate the function of MPO in
discriminating angiographic CAD result, to demonstrate the role of SNPs
599839-12487736 in early onset of CAD and to isolate the role of genetics by
exploring the concomitant effect of consanguinity and disease family history in
determining risk and age at diagnosis of CAD. CAD was determined by cardiac
catheterization. Analysis of variance, chi square, spearman’s correlation, Gensini
score and logistic regression tests were constructed to isolate genetic and
environmental impacts of family history, to determine the genetic impact on
disease expression and age at diagnosis of CAD, and to clarify the role of MPO in
stenosis severity. Family history of CAD and age showed significant risk for
young age at diagnosis of CAD (p <0.001).Consanguinity did not appear to
promote risk of CAD (p =0.375 category 3), but rather significantly associated
with young age of disease diagnosis (p <0.001).MPO levels were not statistically
correlated with Gensini scores. Only rs599389 was significantly associated with
the early onset of CAD. The minor allele G of rs599389 is a protector for early onset of CAD while family history of CAD is a strong promoter of young age at
diagnosis. Furthermore, parental consanguinity in the presence of family history
lowers the age of disease diagnosis significantly for CAD, emphasizing the role of
strong genetic CAD modifiers. These results place the age of disease diagnosis as
an important screening factor in genetic disease association studies.
