Parental consanguinity and family history of coronary artery disease strongly predict early stenosis

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dc.contributor.author Deeb, Mary E.
dc.contributor.author Zreik, Tony G.
dc.contributor.author Zalloua, Pierre
dc.contributor.author Youhanna, Sonia
dc.contributor.author Platt, Daniel E.
dc.contributor.author Rebeiz, Abdallah
dc.contributor.author Lauridsen, Michael
dc.contributor.author Nasrallah, Antoine
dc.contributor.author Alam, Samir
dc.contributor.author Puzantian, Houry
dc.contributor.author Kabbani, Samer
dc.date.accessioned 2016-11-18T14:36:09Z
dc.date.available 2016-11-18T14:36:09Z
dc.date.copyright 2010 en_US
dc.date.issued 2016-11-18
dc.identifier.issn 0021-9150 en_US
dc.identifier.uri http://hdl.handle.net/10725/4833
dc.description.abstract Background Coronary artery disease (CAD) is a multifactorial disease with acquired and inherited components. Aim We investigated the roles of family history and consanguinity on CAD risk and age at diagnosis in 4284 patients. The compounded impact of diabetes, hyperlipidemia, hypertension, smoking, and BMI, which are known CAD risk factors, on CAD risk and age at diagnosis was also explored. Methods CAD was determined by cardiac catheterization. Logistic regression and stratification were performed to determine the impact of family history and consanguinity on risk and onset of CAD, controlling for diabetes, hyperlipidemia, hypertension, smoking, and BMI. Results Family history of CAD and gender significantly increased the risk for young age at diagnosis of CAD (p < 0.001). Consanguinity did not promote risk of CAD (p = 0.38), but did affect age of disease diagnosis (p < 0.001). The mean age at disease diagnosis was lowest, 54.8 years, when both family history of CAD and consanguinity were considered as unique risk factors for CAD, compared to 62.8 years for the no-risk-factor patient category (p < 0.001). Conclusions Family history of CAD and smoking are strongly associated with young age at diagnosis. Furthermore, parental consanguinity in the presence of family history lowers the age of disease diagnosis significantly for CAD, emphasizing the role of strong genetic and cultural CAD modifiers. These findings highlight the increased role of genetic determinants of CAD in some population subgroups, and suggest that populations and family structure influence genetic heterogeneity between patients with CAD. en_US
dc.language.iso en en_US
dc.title Parental consanguinity and family history of coronary artery disease strongly predict early stenosis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200900035 en_US
dc.author.idnumber 200802707 en_US
dc.author.idnumber 200300001 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Atherosclerosis en_US
dc.journal.volume 212 en_US
dc.journal.issue 2 en_US
dc.article.pages 559-563 en_US
dc.article.pages https://orcid.org/0000-0002-8494-5081
dc.keywords CAD en_US
dc.keywords Stenosis en_US
dc.keywords Family History en_US
dc.keywords Consanguinity en_US
dc.keywords Atherosclerosis en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.atherosclerosis.2010.07.013 en_US
dc.identifier.ctation Youhanna, S., Platt, D. E., Rebeiz, A., Lauridsen, M., Deeb, M. E., Nasrallah, A., ... & Zreik, T. G. (2010). Parental consanguinity and family history of coronary artery disease strongly predict early stenosis. Atherosclerosis, 212(2), 559-563. en_US
dc.author.email mary.deeb@lau.edu.lb en_US
dc.author.email tgzreik@lau.edu.lb en_US
dc.author.email pierre.zalloua@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0021915010005551 en_US
dc.author.affiliation Lebanese American University en_US

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