Predictors of neurodevelopmental outcome for preterm infants with brain injury

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dc.contributor.author Deeb, Mary
dc.contributor.author Badr, Lina Kurdahi
dc.contributor.author Bookheimer, Susan
dc.contributor.author Purdy, Isabell
dc.date.accessioned 2016-11-18T12:32:18Z
dc.date.available 2016-11-18T12:32:18Z
dc.date.copyright 2009 en_US
dc.date.issued 2016-11-18
dc.identifier.issn 0378-3782 en_US
dc.identifier.uri http://hdl.handle.net/10725/4828
dc.description.abstract This multi-center correlational prospective study examined early neonatal predictors of neurodevelopment in 59 premature infants (mean birth weight = 1713.8 ± 1242.5 g; mean gestational age = 31.2 ± 3.6 weeks) suspected to have sustained brain injury at birth. The mental and motor development of the infants selected from five university-affiliated hospitals was assessed at baseline (59 infants), 12 (55 infants), and 18 months (46 infants) using Bayley II scales. Factors correlating with Bayley II scores at 12 and 18 months included head circumference, results of neurological and magnetic resonance imaging (MRI) examination at baseline, environmental factors such as mother–infant interactions and levels of parental stress, and infant medical factors such as Apgar scores at 5 min and length of hospital stay. Multiple regression analyses distinguished the most significant predictors of mental and motor development. The best predictors of mental and motor development at 18 months were head circumference, neurological examinations, and MRI results. These findings suggest that in infants suspected of brain injury at birth, neurological assessments and head circumference measurements are just as predictive of developmental outcome at 18 months as MRI, and this is especially relevant in developing countries or other locations where MRI is not possible. The presence of this information may offer the potential of early tailored interventions to improve the mental and motor development of children in developing countries or other facilities where MRI is unavailable. en_US
dc.language.iso en en_US
dc.title Predictors of neurodevelopmental outcome for preterm infants with brain injury en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle MRI, medical and environmental factors en_US
dc.author.school SOM en_US
dc.author.idnumber 200900035 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Early Human Development en_US
dc.journal.volume 85 en_US
dc.journal.issue 5 en_US
dc.article.pages 279-284 en_US
dc.keywords Brain injury en_US
dc.keywords MRI en_US
dc.keywords Neurodevelopment en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.earlhumdev.2008.11.005 en_US
dc.identifier.ctation Badr, L. K., Bookheimer, S., Purdy, I., & Deeb, M. (2009). Predictors of neurodevelopmental outcome for preterm infants with brain injury: MRI, medical and environmental factors. Early human development, 85(5), 279-284. en_US
dc.author.email mary.deeb@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0378378208006269 en_US
dc.author.affiliation Lebanese American University en_US

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