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Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection

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dc.contributor.author Hani, Abeer
dc.contributor.author Nabulsi, Mona
dc.contributor.author Karam, Maria
dc.date.accessioned 2016-11-11T09:36:42Z
dc.date.available 2016-11-11T09:36:42Z
dc.date.copyright 2012 en_US
dc.date.issued 2016-11-11
dc.identifier.issn 1471-2431 en_US
dc.identifier.uri http://hdl.handle.net/10725/4768
dc.description.abstract Background C-reactive protein (CRP) is widely used to detect bacterial infection in children. We investigated the impact of CRP test results on decision-making and summarized the evidence base (EB) of CRP testing. Methods We collected information from the hospital records of 91 neonates with suspected sepsis and of 152 febrile children with suspected infection on the number of ordered CRP tests, the number of EB-CRP tests, and the impact of the test results on decision-making. CRP diagnostic accuracy studies focusing on pediatric infections were reviewed critically. The main outcomes were the proportion of CRP tests that were EB and the proportion of tests that affected decision-making. A secondary outcome was the overall one-year expenditure on CRP testing. Results The current EB for CRP testing in pediatric infections is weak and suggests that CRP is of low diagnostic value. Approximately 54.8% of tests performed for suspected neonatal sepsis and 28% of tests performed for other infections were EB; however, the results of only 12.9% of neonatal sepsis tests and of 29.9% of tests on children with other infections informed decision-making. The one-year overall cost for CRP testing and related health care was $26,715.9. Conclusions The routine ordering of CRP for children with infections is based on weak evidence. The impact of the CRP test results on decision-making is rather small, and CRP ordering may contribute to unnecessary health care expenditures. Better quality research is needed to definitively determine the diagnostic accuracy of CRP levels in children with infections. en_US
dc.language.iso en en_US
dc.title Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201509120 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal BMC Pediatrics en_US
dc.journal.volume 12:140 en_US
dc.journal.issue 1 en_US
dc.article.pages 1-7 en_US
dc.keywords C-reactive protein en_US
dc.keywords Neonatal sepsis en_US
dc.keywords Bacterial infection en_US
dc.keywords Diagnostic accuracy en_US
dc.identifier.doi http://dx.doi.org/10.1186/1471-2431-12-140 en_US
dc.identifier.ctation Nabulsi, M., Hani, A., & Karam, M. (2012). Impact of C-reactive protein test results on evidence-based decision-making in cases of bacterial infection. BMC pediatrics, 12(1), 1-7 en_US
dc.author.email abeer.hani@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-12-140 en_US
dc.author.affiliation Lebanese American University en_US


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