Dosing and Monitoring of Trace Elements in Long-Term Home Parenteral Nutrition Patients

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Carver, Peggy L.
dc.contributor.author Welch, Katheen B.
dc.date.accessioned 2016-10-10T08:18:31Z
dc.date.available 2016-10-10T08:18:31Z
dc.date.copyright 2011 en_US
dc.date.issued 2016-10-10
dc.identifier.issn 0148-6071 en_US
dc.identifier.uri http://hdl.handle.net/10725/4539
dc.description.abstract Background: Trace elements (TEs) dosing and monitoring in home parenteral nutrition (PN) patients vary with their underlying conditions. Methods: This retrospective observational study evaluated parenteral TE dosing, serum TE concentrations and monitoring, and dose-concentration relationships between TE doses and serum TE concentrations in 26 adult and adolescent home PN patients. Results: There was a total of 40,493 PN days. Average parenteral zinc doses of 9.1 mg/d and 7.6 mg/d resulted in the majority of serum zinc concentrations (90%) within normal range in patients with and without short bowel syndrome (SBS), respectively. Selenium at about 70 mcg/d resulted in about 60% of serum selenium concentrations within normal range, with 38% of values below normal in patients with and without SBS alike. Copper at 1 mg/d resulted in 22.5% of serum copper concentrations above the normal range. The majority of serum manganese (94.6%) and chromium (96%) concentrations were elevated. Serum TE concentrations were infrequently monitored. Significant relationships existed between doses and serum concentrations for zinc (P < .0001), manganese (P = .012), and chromium (P < .0001) but not for selenium or copper. Conclusions: TE doses in home PN should be individualized and adjusted based on regular monitoring of TE status. In long-term home PN patients, higher zinc and selenium doses may be necessary to maintain their normal serum concentrations. Lower copper doses and restrictions of manganese and chromium supplementation may be needed to avoid their accumulation. Relationships between TE doses and serum TE concentrations vary for each TE and underlying clinical conditions. en_US
dc.language.iso en en_US
dc.title Dosing and Monitoring of Trace Elements in Long-Term Home Parenteral Nutrition Patients en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Parental and Enteral Nutrition en_US
dc.journal.volume 35 en_US
dc.journal.issue 6 en_US
dc.article.pages 736-747 en_US
dc.keywords Trace elements en_US
dc.keywords Home parenteral nutrition en_US
dc.identifier.doi http://dx.doi.org/10.1006/bbrc.1994.188310.1177/0148607111413902 en_US
dc.identifier.ctation Btaiche, I. F., Carver, P. L., & Welch, K. B. (2011). Dosing and monitoring of trace elements in long-term home parenteral nutrition patients. Journal of Parenteral and Enteral Nutrition, 35(6), 736-747. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://pen.sagepub.com/content/35/6/736.short en_US

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