Sincalide in patients with parenteral nutrition—Associated gallbladder disease

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Prescott, William A.
dc.date.accessioned 2016-10-06T13:50:55Z
dc.date.available 2016-10-06T13:50:55Z
dc.date.copyright 2004 en_US
dc.date.issued 2016-10-06
dc.identifier.issn 1060-0280 en_US
dc.identifier.uri http://hdl.handle.net/10725/4530
dc.description.abstract OBJECTIVE To review the role of sincalide in treating and preventing parenteral nutrition (PN)–associated gallbladder disease. DATA SOURCES A MEDLINE (1996–March 2004) search was performed using the key terms cholecystokinin, sincalide, parenteral nutrition, cholelithiasis, cholestasis, and sludge. DATA SYNTHESIS Five human studies investigated the safety and efficacy of sincalide in patients with PN-associated gallbladder disease. Sincalide at intravenous doses of 0.04 μg/kg 3 times daily increased bile flow and improved serum bilirubin levels. However, patients with advanced liver disease did not respond to sincalide therapy. Long-term follow-up data on sincalide effects on liver disease progression are not yet available. CONCLUSIONS Sincalide improved the signs of cholestasis. However, its long-term effects in preventing and treating PN-associated gallbladder disease remain unknown and its routine use for this indication cannot be recommended at this time. en_US
dc.language.iso en en_US
dc.title Sincalide in patients with parenteral nutrition—Associated gallbladder disease en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Annals of Pharmacotherapy en_US
dc.journal.volume 38 en_US
dc.journal.issue 11 en_US
dc.article.pages 1942-1945 en_US
dc.keywords Gall bladder disease en_US
dc.keywords Parenteral nutrition en_US
dc.keywords Sincalide en_US
dc.identifier.ctation Prescott, W. A., & Btaiche, I. F. (2004). Sincalide in Patients with Parenteral Nutrition—Associated Gallbladder Disease. Annals of Pharmacotherapy, 38(11), 1942-1945. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://aop.sagepub.com/content/38/11/1942.short en_US

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