Oxandrolone Treatment in Adults with Severe Thermal Injury

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Miller, James T.
dc.date.accessioned 2016-10-06T11:46:02Z
dc.date.available 2016-10-06T11:46:02Z
dc.date.copyright 2009 en_US
dc.date.issued 2016-10-06
dc.identifier.issn 0277-0008 en_US
dc.identifier.uri http://hdl.handle.net/10725/4521
dc.description.abstract Severe thermal injury is associated with hypermetabolism and hyper-catabolism, leading to skeletal muscle breakdown, lean body mass loss, weight loss, and negative nitrogen balance. Muscle protein catabolism in patients with severe thermal injury is the result of stress-induced increased release of cytokines and counterregulatory hormones. Coupled with decreased serum anabolic hormone concentrations such as testosterone and growth hormone along with the presence of insulin resistance, anabolism in patients with severe thermal injury is inefficient or impossible during the acute postburn period. This causes difficulty in restoring lean body mass and regaining lost body weight, as well as poor healing of the burn wound and delayed patient recovery. Oxandrolone, a synthetic derivative of testosterone, has been used in adult patients with severe thermal injury to enhance lean body mass accretion, restore body weight, and accelerate wound healing. In clinical studies, oxandrolone 10 mg orally twice/day improved wound healing, restored lean body mass, and accelerated body weight gain. During the rehabilitation period, oxandrolone therapy with adequate nutrition and exercise improved lean body mass, increased muscle strength, and restored body weight. However, most data on oxandrolone use in adult patients with severe thermal injury are derived from single-center studies, many of which enrolled a relatively small number of subjects and some of which had a poor design. Multicenter, prospective, randomized studies are needed to better define the optimal oxandrolone dosage and to confirm the efficacy and safety of this drug in adult patients with severe thermal injury. en_US
dc.language.iso en en_US
dc.title Oxandrolone Treatment in Adults with Severe Thermal Injury en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmacotherapy en_US
dc.journal.volume 29 en_US
dc.journal.issue 2 en_US
dc.article.pages 213-226 en_US
dc.keywords Oxandrolone en_US
dc.keywords Burn en_US
dc.keywords Adults en_US
dc.keywords Thermal injury en_US
dc.identifier.doi http://dx.doi.org/10.1592/phco.29.2.213 en_US
dc.identifier.ctation Miller, J. T., & Btaiche, I. F. (2009). Oxandrolone treatment in adults with severe thermal injury. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 29(2), 213-226. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1592/phco.29.2.213/abstract en_US

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