Trace element removal during in vitro and in vivo continuous haemodialysis

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Churchwell, Mariann D.
dc.contributor.author Pasko, Deborah A.
dc.contributor.author Jain, Jinesh C.
dc.contributor.author Mueller, Bruce A.
dc.date.accessioned 2016-10-06T09:31:35Z
dc.date.available 2016-10-06T09:31:35Z
dc.date.copyright 2007 en_US
dc.date.issued 2016-10-06
dc.identifier.issn 0931-0509 en_US
dc.identifier.uri http://hdl.handle.net/10725/4515
dc.description.abstract Background. Continuous renal replacement therapy (CRRT) increasingly is being used to treat critically ill patients with renal disease. CRRT removes waste products but also nutrients. Our understanding of trace element CRRT clearance has been limited by poor assay sensitivity. The development of inductively coupled plasma mass spectrometry (ICP–MS) allows for the measurement of CRRT trace element removal. Methods. Continuous venovenous haemodialysis (CVVHD) transmembrane clearances of trace elements and urea were assessed using a bovine blood-based in vitro model using two different haemodialyser types. These findings were validated in 10 critically ill adult patients receiving continuous venovenous haemodiafiltration (CVVHDF). Calculated daily trace element loss was compared with a typical dose of daily trace element supplementation. Results. The mean ± SD in vitro CVVHD transmembrane clearances (ml/min) for the polysulfone haemodialyser were chromium 0.97 ± 0.23, copper 0.47 ± 0.18, manganese 4.6 ± 3.6, selenium 1.2 ± 0.63 and zinc 2.3 ± 0.32 and for the cellulose diacetate haemodialyser chromium 1.54 ± 0.91, copper 0.21 ± 0.07, manganese 7.8 ± 4.1, selenium 0.76 ± 0.39 and zinc 2.7 ± 0.37. The in vivo CVVHDF transmembrane clearances (ml/min) were chromium 5.4 ± 2.4, copper 0.45 ± 0.33, manganese 1.9 ± 4.6, selenium 1.6 ± 1.2, and zinc 4.0 ± 1.3. Conclusion. ICP–MS assays detected the five trace elements in the effluent of CVVHDF patients. Trace element CVVHD transmembrane clearance estimates for our in vitro model were supported by the in vivo CVVHDF findings. Calculated daily trace element loss attributed to CVVHD and CVVHDF with dialysate flow rates of 33.3 ml/min is less than what is provided in a daily dose of a trace element supplementation product. en_US
dc.language.iso en en_US
dc.title Trace element removal during in vitro and in vivo continuous haemodialysis en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Nephrology Dialysis Transplantation en_US
dc.journal.volume 22 en_US
dc.journal.issue 10 en_US
dc.article.pages 2970-2977 en_US
dc.keywords Continuous dialysis en_US
dc.keywords Continuous renal replacement therapy en_US
dc.keywords Critically ill en_US
dc.keywords Haemodiafiltration en_US
dc.keywords Nutrition en_US
dc.keywords Trace elements en_US
dc.identifier.doi http://dx.doi.org/10.1093/ndt/gfm352 en_US
dc.identifier.ctation Churchwell, M. D., Pasko, D. A., Btaiche, I. F., Jain, J. C., & Mueller, B. A. (2007). Trace element removal during in vitro and in vivo continuous haemodialysis. Nephrology Dialysis Transplantation, 22(10), 2970-2977. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://ndt.oxfordjournals.org/content/22/10/2970.short en_US

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