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Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN)

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dc.contributor.author Btaiche, Imad
dc.contributor.author Tazuke, Yuko
dc.contributor.author Drongowski, Robert A.
dc.contributor.author Coran, Arnold G.
dc.contributor.author Teitelbaum, Daniel H.
dc.date.accessioned 2016-10-06T09:19:04Z
dc.date.available 2016-10-06T09:19:04Z
dc.date.copyright 2004 en_US
dc.identifier.issn 0179-0358 en_US
dc.identifier.uri http://hdl.handle.net/10725/4514
dc.description.abstract Lipids are an important component of total parenteral nutrition (TPN), contributing the largest caloric load per volume of solution and providing essential fatty acids necessary for survival. However, lipids are known to be causative factors in oxidative stress, which are expressed via the Bcl-2 family of proteins and/or Fas-mediated apoptosis in several tissues. Interestingly, we have recently observed an increase in hepatocyte apoptosis with administration of TPN. To address the mechanism of this apoptosis, we investigated the effects of parenteral lipid administration on apoptotic signaling in a mouse model. C57BL/6J male mice received physiologic saline and standard chow (control) or standard TPN solution with (TPN+L) or without lipid (TPN-L) emulsion. After 7 days of infusion, apoptosis increased in the TPN+L at a significantly higher rate compared with control and TPN-L groups ( p <0.05). Both TPN, with and without lipids, suppressed the pro-apoptotic signals Bid and Bcl-xs ( p <0.05). In contrast, TPN with lipid increased the expression of Fas and both the pro-apoptotic factor Bad and the anti-apoptotic factor Bcl-xl ( p <0.05). These changes may contribute to TPN-induced hepatocyte injury (apoptosis) or suppress the ability of liver hepatocytes to regenerate. en_US
dc.language.iso en en_US
dc.title Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN) en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pediatric Surgery International en_US
dc.journal.volume 20 en_US
dc.journal.issue 4 en_US
dc.article.pages 224-228 en_US
dc.keywords Total parenteral nutrition (TPN) en_US
dc.keywords Lipid en_US
dc.keywords Apoptosis en_US
dc.keywords Hepatocyte en_US
dc.identifier.doi http://dx.doi.org/10.1007/s00383-003-1115-1 en_US
dc.identifier.ctation Tazuke, Y., Drongowski, R. A., Btaiche, I., Coran, A. G., & Teitelbaum, D. H. (2004). Effects of lipid administration on liver apoptotic signals in a mouse model of total parenteral nutrition (TPN). Pediatric surgery international, 20(4), 224-228. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://link.springer.com/article/10.1007/s00383-003-1115-1 en_US


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