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Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Mohammad, Rima A.
dc.contributor.author Alaniz, Cesar
dc.contributor.author Muller, Bruce A.
dc.date.accessioned 2016-10-06T08:42:20Z
dc.date.available 2016-10-06T08:42:20Z
dc.date.copyright 2008 en_US
dc.identifier.issn 0277-0008 en_US
dc.identifier.uri http://hdl.handle.net/10725/4512
dc.description.abstract Acute kidney injury in critically ill patients is often a complication of an underlying condition such as organ failure, sepsis, or drug therapy. In these patients, stress-induced hypercatabolism results in loss of body cell mass. Unless nutrition support is provided, malnutrition and negative nitrogen balance may ensue. Because of metabolic, fluid, and electrolyte abnormalities, optimization of nutrition to patients with acute kidney injury presents a challenge to the clinician. In patients treated with conventional intermittent hemodialysis, achieving adequate amino acid intake can be limited by azotemia and fluid restriction. With the use of continuous renal replacement therapy (CRRT), however, better control of azotemia and liberalization of fluid intake allow amino acid intake to be maximized to support the patient’s metabolic needs. High amino acid doses up to 2.5 g/kg/day in patients treated with CRRT improved nitrogen balance. However, to our knowledge, no studies have correlated increased amino acid intake with improved outcomes in critically ill patients with acute kidney injury. Data from large, prospective, randomized, controlled trials are needed to optimize the dosing of amino acids in critically ill patients with acute kidney injury who are treated with CRRT and to study the safety of high doses and their effects on patient morbidity and survival. en_US
dc.language.iso en en_US
dc.title Amino Acid Requirements in Critically Ill Patients with Acute Kidney Injury Treated with Continuous Renal Replacement Therapy en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmacotherapy en_US
dc.journal.volume 28 en_US
dc.journal.issue 5 en_US
dc.article.pages 600-613 en_US
dc.keywords Renal failure en_US
dc.keywords Acute kidney injury en_US
dc.keywords Critical illness en_US
dc.keywords Continuous renal replacement therapy en_US
dc.keywords CRRT en_US
dc.keywords Amino acids en_US
dc.keywords Nutrition en_US
dc.identifier.doi http://dx.doi.org/10.1592/phco.28.5.600 en_US
dc.identifier.ctation Btaiche, I. F., Mohammad, R. A., Alaniz, C., & Mueller, B. A. (2008). Amino acid requirements in critically ill patients with acute kidney injury treated with continuous renal replacement therapy. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 28(5), 600-613. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1592/phco.28.5.600/abstract en_US


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