Parenteral nutrition-associated liver complications in children

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Khalidi, Nabil
dc.date.accessioned 2016-10-06T07:29:41Z
dc.date.available 2016-10-06T07:29:41Z
dc.date.copyright 2002 en_US
dc.date.issued 2016-10-06
dc.identifier.issn 0277-0008 en_US
dc.identifier.uri http://hdl.handle.net/10725/4510
dc.description.abstract Parenteral nutrition is a life-saving therapy for patients with intestinal failure. It may be associated with transient elevations of liver enzyme concentrations, which return to normal after parenteral nutrition is discontinued. Prolonged parenteral nutrition is associated with complications affecting the hepatobiliary system, such as cholelithiasis, cholestasis, and steatosis. The most common of these is parenteral nutrition-associated cholestasis (PNAC), which may occur in children and may progress to liver failure. The pathophysiology of PNAC is poorly understood, and the etiology is multifactorial. Risk factors include prematurity, long duration of parenteral nutrition, sepsis, lack of bowel motility, and short bowel syndrome. Possible etiologies include excessive caloric administration, parenteral nutrition components, and nutritional deficiencies. Several measures can be undertaken to prevent PNAC, such as avoiding overfeeding, providing a balanced source of energy, weaning parenteral nutrition, starting enteral feeding, and avoiding sepsis. en_US
dc.language.iso en en_US
dc.title Parenteral nutrition-associated liver complications in children en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmacotherapy en_US
dc.journal.volume 22 en_US
dc.journal.issue 2 en_US
dc.article.pages 188-211 en_US
dc.identifier.doi http://dx.doi.org/10.1592/phco. en_US
dc.identifier.ctation Btaiche, I. F., & Khalidi, N. (2002). Parenteral Nutrition‐Associated Liver Complications in Children. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 22(2), 188-211. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1592/phco. en_US

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