Relationship Between Hyperglycemia and Infection in Critically Ill Patients

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dc.contributor.author Btaiche, Imad F.
dc.contributor.author Butler, Simona O.
dc.date.accessioned 2016-10-05T11:55:20Z
dc.date.available 2016-10-05T11:55:20Z
dc.date.copyright 2005 en_US
dc.date.issued 2016-10-05
dc.identifier.issn 0277-0008 en_US
dc.identifier.uri http://hdl.handle.net/10725/4509
dc.description.abstract Hyperglycemia is a common problem encountered in hospitalized patients, especially in critically ill patients and those with diabetes mellitus. Uncontrolled hyperglycemia may be associated with complications such as fluid and electrolyte disturbances and increased infection risk. Studies have demonstrated impairment of host defenses, including decreased polymorphonuclear leukocyte mobilization, chemotaxis, and phagocytic activity related to hyperglycemia. Until 2001, hyperglycemia (blood glucose concentrations up to 220 mg/dl) had been tolerated in critically ill patients not only because high blood glucose concentrations were believed to be a normal physiologic reaction in stressed patients and excess glucose is necessary to support the energy needs of glucose-dependent organs, but also because the true significance of short-term hyperglycemia was not known. Recent clinical data show that the use of intensive insulin therapy to maintain tight blood glucose concentrations between 80 and 110 mg/dl decreases morbidity and mortality in critically ill surgical patients. Intensive insulin therapy minimizes derangements in normal host defense mechanisms and modulates release of inflammatory mediators. The principal benefit of intensive insulin therapy is a decrease in infection-related complications and mortality. Further research will define which patient populations will benefit most from intensive insulin therapy and firmly establish the blood glucose concentration at which benefits will be realized. en_US
dc.language.iso en en_US
dc.title Relationship Between Hyperglycemia and Infection in Critically Ill Patients en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201105289 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal Pharmacotherapy en_US
dc.journal.volume 25 en_US
dc.journal.issue 7 en_US
dc.article.pages 963–976 en_US
dc.identifier.doi http://dx.doi.org/10.1592/phco.2005.25.7.963 en_US
dc.identifier.ctation Butler, S. O., Btaiche, I. F., & Alaniz, C. (2005). Relationship between hyperglycemia and infection in critically ill patients. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 25(7), 963-976. en_US
dc.author.email imad.btaiche@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://onlinelibrary.wiley.com/doi/10.1592/phco.2005.25.7.963/abstract en_US

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