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Oritavancin

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dc.contributor.author Karaoui, Lamis R.
dc.contributor.author El-Lababidi, Rania
dc.contributor.author Chahine, Elias B.
dc.date.accessioned 2016-09-30T11:25:08Z
dc.date.available 2016-09-30T11:25:08Z
dc.date.copyright 2013 en_US
dc.identifier.issn 1079-2082 en_US
dc.identifier.uri http://hdl.handle.net/10725/4467
dc.description.abstract Purpose. The pharmacology, unique pharmacokinetic-pharmacodynamic profile,and potential future role of oritavancin in combating multidrug-resistant infections are reviewed, with an emphasis on efficacy data from Phase II and III clinical trials.Summary. Oritavancin has been shown to have potent in vitro activity against vancomycin-resistant enterococci (VRE)and staphylococci, methicillin-resistantStaphylococcus aureus (MRSA), and grampositiveanaerobic bacteria. Oritavancin exhibits excellent tissue penetration and concentrates well in macrophages; its prolonged plasma half-life (195.4 hours) and extended in vitro post-antibiotic effect (2.4-7.7 hours for MRSA and 1.9-4.3 hours for VRE) might allow once-daily or alternate-day dosing. Oritavancin has been shown to have synergistic activity with several antibiotics(e.g., ampicillin, gentamicin, linezolid)against certain infections. In two Phase III clinical trials involving a total of about 1800patients with complicated skin and skin structure infections (cSSSIs), i.v. oritavancin therapy was shown to have bactericidal activity and a safety profile comparable to those of i.v. vancomycin (plus optional oral cephalexin stepdown therapy) while requiring a significantly shorter duration of therapy; however, the compiled evidence was considered insufficient to justify marketing approval by the Food and Drug Administration,which requested additional safety and efficacy data. Two ongoing Phase III trials evaluating oritavancin for the treatment of acute bacterial SSSIs are expected to be completed in early 2013.During the clinical trials to date, the most commonly reported adverse effects among oritavancin users were headache, nausea,constipation, and phlebitis.Conclusion. Oritavancin is an investigational semisynthetic antibiotic classified as a second-generation lipoglycopeptide,with promising activity against multidrugresistantgram-positive pathogens. en_US
dc.language.iso en en_US
dc.title Oritavancin en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle An investigational lipoglycopeptide antibiotic en_US
dc.author.school SOP en_US
dc.author.idnumber 200101817 en_US
dc.author.department Pharmacy Practice Department en_US
dc.description.embargo N/A en_US
dc.relation.journal American Journal of Health-System Pharmacy en_US
dc.journal.volume 70 en_US
dc.journal.issue 1 en_US
dc.article.pages 23-33 en_US
dc.identifier.doi http://dx.doi.org/10.2146/ajhp110572 en_US
dc.identifier.ctation Karaoui, L. R., El-Lababidi, R., & Chahine, E. B. (2013). Oritavancin: An investigational lipoglycopeptide antibiotic. American Journal of Health-System Pharmacy, 70(1). en_US
dc.author.email lamis.karaoui@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://web.b.ebscohost.com/ehost/detail/detail?sid=322c4593-bc1c-47b7-a3e9-5559989aaad0%40sessionmgr105&vid=0&hid=107&bdata=JnNpdGU9ZWhvc3QtbGl2ZQ%3d%3d#AN=84656123&db=a9h en_US


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