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The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels

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dc.contributor.author Mansour, Hanine
dc.contributor.author Bush, Jeffrey A
dc.contributor.author Brito, Micheal
dc.contributor.author Novonty, Paul
dc.contributor.author Courtney, Cale
dc.contributor.author Mustonen, Jordan
dc.contributor.author Towey, Kim
dc.date.accessioned 2016-09-30T05:54:56Z
dc.date.available 2016-09-30T05:54:56Z
dc.date.copyright 2014 en_US
dc.identifier.issn 0975–1491 en_US
dc.identifier.uri http://hdl.handle.net/10725/4461
dc.description.abstract Objective: To assess the effect of vancomycin doses greater than 2 grams on renal function and vancomycin trough levels Methods: This is a retrospective, pharmacokinetic study performed in a tertiary care level II trauma center. 3579 electronic charts of patients who received vancomcyin at the medical facility between January 2010 and December 2011 were reviewed. Only 30 patients met the inclusion criteria of the study. Included patients were those who were at least 18 years of age who received doses greater than 2 grams of vancomycin for at least 48 hours. Patients in the intensive care units, pregnant or on hemodialysis and were not included in the study. The mean weight for the participants was 154.67 kg. Results: Patients were dosed based on the institution’s vancomycin dosing protocol such as 15-20 mg/kg per dose where the frequency was determined based on the estimated creatinine clearance using cockroft gault equation. A loading dose of 25-30 mg/kg was administered in few cases. Two out of thirty subjects had shown an increase of serum creatinine of ≥ 0.3mg/dL when receiving maintenance doses greater than 2 grams of vancomycin. A Z approximation test was used where a standard error of 0.043 with an α error equal to 0.05 and a 95% confidence interval of (-0.024-0.144) were found. The use of doses greater than 2 grams of IV vancomycin did not show a statistically significance increase in serum creatinine. The two subjects who did have a significant increase in serum creatinine were receiving concomitant nephrotoxins. Conclusion: The use of doses greater than 2 grams of IV vancomycin did not show a statistically significant increase in serum creatinine. Patients whom serum creatinine increased were on other nephrotoxin agents that could have contributed to the acute kidney injury that was seen in these patients. en_US
dc.language.iso en en_US
dc.title The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201205628 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal International Journal of Pharmacy and Pharmaceutical Sciences en_US
dc.journal.volume 6 en_US
dc.journal.issue 8 en_US
dc.keywords Vancomycin en_US
dc.keywords Creatinine en_US
dc.keywords Nephrotoxins en_US
dc.keywords Renal function en_US
dc.identifier.ctation Mansour, H., Bush, J. A., Brito, M., Novotny, P., Courtney, C., Mustonen, J., & Towey, K. (2014). The effect of vancomycin doses greater than 2 grams on serum creatinine and vancomycin trough levels. International Journal of Pharmacy and Pharmaceutical Sciences, 6(8), 621-625. en_US
dc.author.email hanine.mansour@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://innovareacademics.in/journals/index.php/ijpps/article/view/2791 en_US


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