Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep

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dc.contributor.author Abouantoun, Tamara
dc.contributor.author Dodic, Miodrag
dc.contributor.author O'Connor, Anne
dc.contributor.author Wintour, E. Marelyn
dc.contributor.author Moritz, Karen M.
dc.date.accessioned 2016-09-27T11:48:24Z
dc.date.available 2016-09-27T11:48:24Z
dc.date.copyright 2002 en_US
dc.date.issued 2016-09-27
dc.identifier.issn 0194-911X en_US
dc.identifier.uri http://hdl.handle.net/10725/4428
dc.description.abstract Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe between 26 to 28 days of gestation (1) resulted in high blood pressure in male and female offspring and whether hypertension in males was modulated by testosterone status, and (2) altered gene expression for angiotensinogen and angiotensin type 1 (AT1) receptors in the brain in late gestation and in the adult. Basal mean arterial pressure (MAP) at 2 years of age was significantly higher in wethers exposed to prenatal dexamethasone (group D; 106 5 mm Hg, n9) compared with the control group (group S; 91 3 mm Hg, n8; P0.01). Infusion of testosterone for 3 weeks had no effect on MAP in either treatment group. At 130 days of gestation, dexamethasone administered between 26 to 28 days of gestation (group DF; n8), resulted in an increased expression of angiotensinogen in hypothalamus (in arbitrary units: 2.5 0.3 versus 1.3 0.3 in the saline group [group SF], n10; P0.05). In addition, there was higher expression of the AT1 receptors in medulla oblongata in group DF (2.6 0.6 versus 1.1 0.2 in group SF; P0.01). This effect of prenatal dexamethasone treatment was still evident in females at 7 years of age (group DA; n5; 2.6 0.5 versus 1.1 0.2 in group SA; n6, P0.05). In conclusion, brief prenatal exposure of the pregnant ewe to dexamethasone leads to hypertension in adult animals of both sexes. Most interestingly, the mechanism leading to programming of hypertension might be linked with the brain angiotensin system. (Hyperte en_US
dc.language.iso en en_US
dc.title Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201005279 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Hypertension en_US
dc.journal.volume 40 en_US
dc.journal.issue 5 en_US
dc.article.pages 729-734 en_US
dc.keywords Brain en_US
dc.keywords Glucocorticoids en_US
dc.keywords Hypertension, experimental en_US
dc.keywords Sheep en_US
dc.identifier.doi http://dx.doi.org/10.1161/01.HYP.0000036455.62159.7E en_US
dc.identifier.ctation Dodic, M., Abouantoun, T., O’Connor, A., Wintour, E. M., & Moritz, K. M. (2002). Programming effects of short prenatal exposure to dexamethasone in sheep. Hypertension, 40(5), 729-734. en_US
dc.author.email tamara.abouantoun@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://hyper.ahajournals.org/content/40/5/729.full en_US

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