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Renin–angiotensin-system gene polymorphisms and depression

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dc.contributor.author Saab, Yolande B.
dc.contributor.author Gard, Paul R.
dc.contributor.author Yeoman, Mark S.
dc.contributor.author Mfarref, Bechara
dc.contributor.author El-Moalen, Bechara
dc.date.accessioned 2016-09-26T09:31:52Z
dc.date.available 2016-09-26T09:31:52Z
dc.date.copyright 2007 en_US
dc.identifier.issn 0278-5846 en_US
dc.identifier.uri http://hdl.handle.net/10725/4390
dc.description.abstract Given the abundance of the renin–angiotensin system (RAS) components in the brain, their importance in behavior and cognition, and the data that implicates them in the etiology and treatment of depression, it is possible that those RAS gene polymorphisms associated with increased RAS activity may also be associated with depression. The frequencies of common polymorphisms of genes encoding for components of the RAS, namely angiotensinogen (M235T), angiotensin converting enzyme (ACE) (insertion, I; deletion, D), angiotensin receptor type I (A1166C), and angiotensin receptor type II (C3123A) were determined in DNA extracted from buccal cells from a Lebanese population of 132 depressed patients and their first-degree relative case-controls. The angiotensin receptor type 1 (A1166C) CC genotype was significantly associated with depression (p = 0.036). None of the other common RAS-associated polymorphisms were significantly associated. The results support the hypothesis that increased RAS activity may increase relative risk of depression in that the angiotensin receptor type 1 (A1166C) CC genotype is associated with increased responsiveness to angiotensin II. en_US
dc.language.iso en en_US
dc.title Renin–angiotensin-system gene polymorphisms and depression en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 199110360 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Progress in Neuro-Psychopharmacology and Biological Psychiatry en_US
dc.journal.volume 31 en_US
dc.journal.issue 5 en_US
dc.article.pages 1113-1118 en_US
dc.keywords Angiotensin en_US
dc.keywords Angiotensin-converting enzyme en_US
dc.keywords Angiotensin receptors en_US
dc.keywords Depression en_US
dc.keywords Gene polymorphism en_US
dc.identifier.doi http://dx.doi.org/10.1016/j.pnpbp.2007.04.002 en_US
dc.identifier.ctation Saab, Y. B., Gard, P. R., Yeoman, M. S., Mfarrej, B., El-Moalem, H., & Ingram, M. J. (2007). Renin–angiotensin-system gene polymorphisms and depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(5), 1113-1118. en_US
dc.author.email ysaab@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0278584607001339 en_US


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