Cytochrome P450 2D6 polymorphism in white Lebanese population

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dc.contributor.author Saab, Yolande
dc.contributor.author Saade, Sarita
dc.contributor.author Mroueh, Mohamad
dc.date.accessioned 2016-09-26T09:25:09Z
dc.date.available 2016-09-26T09:25:09Z
dc.date.copyright 2006 en_US
dc.date.issued 2016-09-26
dc.identifier.issn 1537-064X en_US
dc.identifier.uri http://hdl.handle.net/10725/4389
dc.description.abstract Objective: Genetic, environmental, physiological and pathophysiological factors contribute to the interindividual variability in drug metabolism and response. Among the different cytochromes responsible for drug disposition, cytochrome P450 2D6 (CYP2D6) is a polymorphic enzyme accountable for the clearance of 25% to 30% of medications used including cardiovascular and neuroactive drugs. Severe clinical implications can result from CYP2D6 polymorphism, hence the significance of studying the incidence of different phenotypes in the white Lebanese population. Methods: A 30-mg dose of dextromethorphan hydrobromide was administered to 156 volunteers. Urine samples were collected 8 hours after dextromethorphan administration then stored at -80[degrees]C until analysis for dextromethorphan levels and its metabolites using a sensitive, simple high-performance liquid chromatography assay. Results: The distribution frequency histogram of CYP2D6 metabolic ratios (MRs) showed a bimodal distribution with a gap between the metabolic ratios of 0.14 and 0.31 corresponding to log MR between -0.85 and -0.51. This gap correlates well with the antimode of MR=0.3 reported by previous studies in white populations. Sixteen subjects were classified as poor metabolizers accounting for 10.25% of the whole population sample with metabolic ratios ranging from 0.31 to 25.77; in contrast, 140 (89.75%) volunteers were found to be extensive metabolizers exhibiting MRs between 0.000439 and 0.139. Conclusions: The findings demonstrated the presence of a high proportion of CYP2D6 poor metabolizers in the white Lebanese population and hence the significance of potential clinical implications in these subjects. en_US
dc.language.iso en en_US
dc.title Cytochrome P450 2D6 polymorphism in white Lebanese population en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 199110360 en_US
dc.author.idnumber 199590020
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Journal of Applied Research en_US
dc.journal.volume 6 en_US
dc.journal.issue 1 en_US
dc.article.pages 89 en_US
dc.keywords Cytochrome P450 2D6 en_US
dc.keywords Metabolism en_US
dc.keywords Phamacogenetics en_US
dc.identifier.ctation Saade, S., Mroueh, M., & Saab, Y. (2006). Cytochrome P450 2D6 polymorphism in white Lebanese population. JOURNAL OF APPLIED RESEARCH IN CLINICAL AND EXPERIMENTAL THERAPEUTICS, 6(1), 89. en_US
dc.author.email ysaab@lau.edu.lb en_US
dc.author.email mmroueh@lau.edu.lb
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.biomedsearch.com/article/Cytochrome-P450-2D6-polymorphism-in/159491758.html en_US

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