Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia

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dc.contributor.author Mansour, Hanine
dc.contributor.author Saad, Aline
dc.contributor.author Azar, Marina
dc.contributor.author Khoueiry, Paul
dc.date.accessioned 2016-09-23T12:44:28Z
dc.date.available 2016-09-23T12:44:28Z
dc.date.copyright 2014 en_US
dc.date.issued 2016-09-23
dc.identifier.issn 0018-5787 en_US
dc.identifier.uri http://hdl.handle.net/10725/4360
dc.description.abstract Introduction and Objective: Drug-induced thrombocytopenia is a common adverse effect reported in the literature. Typically patients present with a low platelet count with signs and symptoms ranging from bruising to bleeding, and major organ damage. Penicillin-induced thrombocytopenia previously reported in the literature is explained primarily through the hapten-dependent antibody process. The goal of this report is to present a case of an amoxicillin/clavulanic acid-induced thrombocytopenia. Case Presentation: A 23-year-old male presented to the emergency department with bruises on his arms and legs after completing a full course of amoxicillin/clavulanic acid of 625 mg twice a day for 5 days for tonsillitis. After several tests, the patient was diagnosed with thrombocytopenia induced by amoxicillin/clavulanic acid. The patient was treated with a corticosteroids taper regimen for 3 weeks. He was discharged after 3 days of inpatient treatment with instructions to avoid physical activity for 2 weeks. Two weeks post discharge, the follow-up showed that the platelet count had increased. Discussion: Penicillin-induced thrombocytopenia has been previously reported in the inpatient setting where bleeding was observed. However, the patient in this case report presented with bruises on his arms and legs. The diagnosis was made by the process of elimination; not all possible tests were conducted. The patient was prescribed corticosteroids that are not indicated for drug-induced thrombocytopenia. The Naranjo scale showed that this is a probable adverse event of amoxicillin/clavulanic acid. Conclusion: This is a unique case where amoxicillin/clavulanic acid was reported to be a probable cause of thrombocytopenia in an outpatient setting without signs of bleeding and without concomitant medications en_US
dc.language.iso en en_US
dc.title Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.idnumber 201205628
dc.author.department Pharmacy Practice en_US
dc.description.embargo N/A en_US
dc.relation.journal Hospitality Pharmacy en_US
dc.journal.volume 49 en_US
dc.journal.issue 10 en_US
dc.article.pages 956-960 en_US
dc.keywords Amoxicillin/clavulanic acid en_US
dc.keywords Drug-induced en_US
dc.keywords Platelets en_US
dc.keywords Thrombocytopenia en_US
dc.identifier.doi http://dx.doi.org/10.1310/hpj4910-956 en_US
dc.identifier.ctation Mansour, H., Saad, A., Azar, M., & Khoueiry, P. (2014). Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia. Hospital Pharmacy, 49(10), 956-960. en_US
dc.author.email hanine.mansour@lau.edu.lb
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://journals.sagepub.com/doi/full/10.1310/hpj4910-956 en_US
dc.orcid.id https://orcid.org/0000-0001-6383-0288

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