Osteosynthesis of diaphyseal fracture by Ossatite® Experimental study in rat

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dc.contributor.author El Hayek, T.
dc.contributor.author Griffet, |J.
dc.contributor.author Chevallier, A.
dc.contributor.author Accorsi, E.
dc.contributor.author Odin, G.
dc.contributor.author Pebeyre, B.
dc.date.accessioned 2016-09-20T11:57:06Z
dc.date.available 2016-09-20T11:57:06Z
dc.date.copyright 1999 en_US
dc.date.issued 2016-09-20
dc.identifier.issn 0142-9612 en_US
dc.identifier.uri http://hdl.handle.net/10725/4324
dc.description.abstract In order to develop a biodegradable interlocking nail for fracture fixation, hydoxylapatite pins and paste were implanted in the femoral bone of rats. A distal fracture was performed. The union and the tissue reaction to hydroxylapatite versus stainless-steel rods were studied after 15 days, 1, 2 and 6 months implantation. Metal pins induced a union. Hydroxylapatite pins (Ossatite®) did not prevent callus formation, but did not lead to consolidation in all cases due to weakness of gelatin matrix binding the apatite particles together. The biocompatility of material is satisfactory and the osteo-inductive properties of hydroxylapatite was confirmed. With injectable Ossatite®, we could not obtain rat femoral fracture consolidation. We can confirm good biomaterial tolerance in bone which contrasts with important soft tissue reactions. Use of such material should be carefully limited to filling intra-osseous cavities. en_US
dc.language.iso en en_US
dc.title Osteosynthesis of diaphyseal fracture by Ossatite® Experimental study in rat en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 201205678 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Biomaterials en_US
dc.journal.volume 20 en_US
dc.journal.issue 6 en_US
dc.article.pages 511-515 en_US
dc.keywords Apatite en_US
dc.keywords Fracture healing en_US
dc.keywords Union en_US
dc.keywords Tissue reaction en_US
dc.identifier.doi http://dx.doi.org/10.1006/bbrc.1994.188310.1016/S0142-9612(98)00196-3 en_US
dc.identifier.ctation Griffet, J., Chevallier, A., Accorsi, E., El Hayek, T., Odin, G., & Pebeyre, B. (1999). Osteosynthesis of diaphyseal fracture by Ossatite® Experimental study in rat. Biomaterials, 20(6), 511-515. en_US
dc.author.email toni.hayek@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S0142961298001963 en_US

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