Association of hypertension with coronary artery disease onset in the Lebanese population

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dc.contributor.author Milane, Aline
dc.contributor.author Abdallah, Jad
dc.contributor.author Kanbar, Roy
dc.contributor.author Khazen, Georges
dc.contributor.author Saad, Aline
dc.contributor.author Ghassibe-Sabbagh, Michella
dc.contributor.author Salloum, Angelique K.
dc.contributor.author Youhanna, Sonia
dc.contributor.author Saad, Aline
dc.contributor.author El Bayeh, Hamid
dc.contributor.author Chammas, Elie
dc.contributor.author Platt, Daniel E.
dc.contributor.author Hager, Jorg
dc.contributor.author Gauguier, Dominique
dc.contributor.author Zalloua, Pierre
dc.date.accessioned 2016-07-19T10:40:01Z
dc.date.available 2016-07-19T10:40:01Z
dc.date.copyright 2014 en_US
dc.date.issued 2017-04-11
dc.identifier.issn 2193-1801 en_US
dc.identifier.uri http://hdl.handle.net/10725/4171
dc.description.abstract The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension and CAD age of onset in the Lebanese population. This retrospective analysis was performed on data extracted from Lebanese patients (n = 3,753). Logistic regression examined the association of hypertension with the age at CAD diagnosis after controlling for other traditional risk factors. The effect of antihypertensive drugs and lifestyle changes on the onset of CAD was also investigated. Results showed that hypertension is associated with late onset CAD (OR=0.656, 95% CI=0.504-0.853, p=0.001). Use of antihypertensive drugs showed a similar association with delayed CAD onset. When comparing age of onset in CAD patients with traditional risk factors such as hypertension, diabetes, hyperlipidemia, obesity, smoking and family history of CAD, the age of onset was significantly higher for patients with hypertension compared to those with any of the other risk factors studied (p < 0.001). In conclusion, hypertension and its treatment are associated with late coronary atherosclerotic manifestations in Lebanese population. This observation is currently under investigation to clarify its genetic and/or environmental mechanisms. en_US
dc.language.iso en en_US
dc.title Association of hypertension with coronary artery disease onset in the Lebanese population en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOP en_US
dc.author.school SAS
dc.author.idnumber 200904164 en_US
dc.author.idnumber 200703820 en_US
dc.author.idnumber 201005298
dc.author.idnumber 201105253
dc.author.idnumber 200703818
dc.author.idnumber 200300001
dc.author.department Pharmaceutical Sciences Department en_US
dc.description.embargo N/A en_US
dc.relation.journal SpringerPlus en_US
dc.journal.volume 3 en_US
dc.article.pages 533-539 en_US
dc.keywords Hypertension en_US
dc.keywords Coronary artery disease (CAD) en_US
dc.keywords Risk factors en_US
dc.keywords Antihypertensive drugs en_US
dc.keywords Therapeutic lifestyle changes en_US
dc.keywords Lebanese population en_US
dc.identifier.doi http://dx.doi.org/10.1186/2193-1801-3-533 en_US
dc.identifier.ctation Milane, A., Abdallah, J., Kanbar, R., Khazen, G., Ghassibe-Sabbagh, M., Salloum, A. K., ... & Platt, D. E. (2014). Association of hypertension with coronary artery disease onset in the Lebanese population. SpringerPlus, 3(1), 533-539 en_US
dc.author.email aline.milane@lau.edu.lb en_US
dc.author.email jabdallah@lau.edu.lb en_US
dc.author.email roy.kanbar@lau.edu.lb
dc.author.email GKhazen@lau.edu.lb
dc.author.email aline.saad@lau.edu.lb
dc.author.email pierre.zalloua@lau.edu.lb
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://springerplus.springeropen.com/articles/10.1186/2193-1801-3-533 en_US
dc.orcid.id https://orcid.org/0000-0001-5267-4953 en_US
dc.orcid.id https://orcid.org/0000-0001-5450-6443 en_US

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