Abstract:
We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.
Citation:
Del Marmol, V., Ito, S., Jackson, I., Vachtenheim, J., Berr, P., Ghanem, G., ... & Huez, G. (1993). TRP‐1 expression correlates with eumelanogenesis in human pigment cells in culture. FEBS letters, 327(3), 307-310.
