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Achieving low-density lipoprotein cholesterol treatment goals among dyslipidemic individuals in the Levant

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dc.contributor.author Ghanem, Georges
dc.contributor.author Hammoudeh, Ayman J.
dc.contributor.author Echtay, Akram
dc.contributor.author Haddad, Jihad
dc.date.accessioned 2016-06-15T07:35:10Z
dc.date.available 2016-06-15T07:35:10Z
dc.date.copyright 2014 en_US
dc.identifier.issn 0300-7995 en_US
dc.identifier.uri http://hdl.handle.net/10725/4038
dc.description.abstract Background: Jump to section Background: Design and methods: Results: Conclusions: Introduction Methods Results Discussion Conclusions Transparency Several studies that evaluated achieving lipid goals have demonstrated an undertreatment of dyslipidemia. We evaluated the use and efficacy of lipid-lowering agents (LLAs) in reducing low-density lipoprotein cholesterol (LDL-C) to recommended levels in the Levant region. Design and methods: Jump to section Background: Design and methods: Results: Conclusions: Introduction Methods Results Discussion Conclusions Transparency A multi-center, cross-sectional survey enrolled 1002 dyslipidemic patients (August 2010 – January 2011) on LLAs for ≥3 months. Collection of data and blood samples was done over one visit. Physicians and patients filled out questionnaires pertaining to dyslipidemia diagnosis and treatment. LDL-C target levels were defined according to international guidelines. Results: Jump to section Background: Design and methods: Results: Conclusions: Introduction Methods Results Discussion Conclusions Transparency The full analysis set included 992 patients. Mean age was 58.0 ± 11.6 years (41% women, 65.7% diabetics and 51.5% had history of coronary heart disease). LLAs were prescribed for primary prevention or secondary prevention or familial hypercholesterolemia in 45.8% and 52.8% and 1.4% of patients; respectively. Overall, 64.0% and 56.8% of the patients attained their LDL-C goal recommended by the NCEP ATP III and TJETF guidelines, respectively. According to the 2004 NCEP ATP III updated guidelines, about 24.8% of the very high risk group attained their LDL goal of ≤70 mg/dL. Smoking, diabetes, metabolic syndrome, history of cardiovascular disease, increased waist circumference, and elevated pre-treatment LDL-C level were all associated with not reaching LDL-C goals. Conclusions: Jump to section Background: Design and methods: Results: Conclusions: Introduction Methods Results Discussion Conclusions Transparency Although the study cohort was a relatively high risk group and might not be representative of the general population, we found that about 60% of enrolled individuals achieved the LDL-C treatment goals and 24.8% of the very high risk group achieved the recommended LDL-C targets of ≤70 mg/dl; national strategies and aggressive awareness campaigns to effectively control lipid levels to recommended target levels, especially in the high risk groups, are urgently needed. en_US
dc.language.iso en en_US
dc.title Achieving low-density lipoprotein cholesterol treatment goals among dyslipidemic individuals in the Levant en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle the CEntralized Pan-Levant survey on tHE Undertreatment of hypercholeSterolemia (CEPHEUS) study en_US
dc.author.school SOM en_US
dc.author.idnumber 201000163 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Current Medical Research and Opinion en_US
dc.journal.volume 30 en_US
dc.journal.issue 10 en_US
dc.article.pages 1957-1965 en_US
dc.keywords Cardiovascular diseases en_US
dc.keywords Low-density lipoprotein cholesterol en_US
dc.keywords Statins en_US
dc.keywords Treatment goals en_US
dc.identifier.doi http://dx.doi.org/ 10.1007/BF0012365710.1185/03007995.2014.929095 en_US
dc.identifier.ctation Hammoudeh, A. J., Echtay, A., Ghanem, G. Y., & Haddad, J. (2014). Achieving low-density lipoprotein cholesterol treatment goals among dyslipidemic individuals in the Levant: the CEntralized Pan-Levant survey on tHE Undertreatment of hypercholeSterolemia (CEPHEUS) study. Current medical research and opinion, 30(10), 1957-1965. en_US
dc.author.email george.ghanem@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.tandfonline.com/doi/abs/10.1185/03007995.2014.929095 en_US


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