Outcome of home parenteral nutrition in 251 children over a 14-y period

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dc.contributor.author Abi Nader, Elie
dc.contributor.author Lambe, Cecile
dc.contributor.author Talbotec, Cecile
dc.contributor.author Pigneur, Benedicte
dc.contributor.author Lacaille, Florence
dc.contributor.author Garnier-Lengline, Helene
dc.date.accessioned 2016-06-09T09:23:01Z
dc.date.available 2016-06-09T09:23:01Z
dc.date.copyright 2016 en_US
dc.date.issued 2016-06-09
dc.identifier.issn 0002-9165 en_US
dc.identifier.uri http://hdl.handle.net/10725/3995
dc.description.abstract Background: Parenteral nutrition (PN) is the main treatment for intestinal failure. Objective: We aimed to review the indications for home parenteral nutrition (HPN) in children and describe the outcome over a 14-y period from a single center. Design: We conducted a retrospective study that included all children who were referred to our institution and discharged while receiving HPN between 1 January 2000 and 31 December 2013. The indications for HPN were divided into primary digestive diseases (PDDs) and primary nondigestive diseases (PNDDs). We compared our results to a previous study that was performed in our unit from 1980 to 2000 and included 302 patients. Results: A total of 251 patients were included: 217 (86%) had a PDD. The mean ± SD age at HPN onset was 0.7 ± 0.3 y, with a mean duration of 1.9 ± 0.4 y. The indications for HPN were short bowel syndrome (SBS) (59%), PNDD (14%), congenital enteropathies (10%), chronic intestinal pseudo-obstruction syndromes (9%), inflammatory bowel diseases (5%), and other digestive diseases (3%). By 31 December 2013, 52% of children were weaned off of HPN, 9% of the PDD subgroup had intestinal transplantation, and 10% died mostly because of immune deficiency. The major complications of HPN were catheter-related bloodstream infections (CRBSIs) (1.7/1000 d of PN) and intestinal failure-associated liver disease (IFALD) (51 children; 20% of cohort). An increased rate of CRBSIs was observed compared with our previous study, but we saw a decreasing trend since 2012. No noteworthy deceleration of growth was observed in SBS children 6 mo after weaning off HPN. Conclusions: SBS was the major indication for HPN in our cohort. IFALD and CRBSIs were potentially life-threatening problems. Nevertheless, complication rates were low, and deaths resulted mostly from the underlying disease. en_US
dc.language.iso en en_US
dc.title Outcome of home parenteral nutrition in 251 children over a 14-y period en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle report of a single center en_US
dc.author.school SOM en_US
dc.author.idnumber 201004801 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal The American Journal of Clinical Nutrition en_US
dc.journal.volume 103 en_US
dc.journal.issue 5 en_US
dc.article.pages 1327-1336 en_US
dc.keywords Home parenteral nutrition en_US
dc.keywords Children en_US
dc.keywords Outcome en_US
dc.keywords Complications en_US
dc.keywords Growth en_US
dc.identifier.doi http://dx.doi.org/10.3945/​ajcn.115.121756 en_US
dc.identifier.ctation Nader, E. A., Lambe, C., Talbotec, C., Pigneur, B., Lacaille, F., Garnier-Lengliné, H., ... & Aigrain, Y. (2016). Outcome of home parenteral nutrition in 251 children over a 14-y period: report of a single center. The American journal of clinical nutrition, 103(5), 1327-1336. en_US
dc.author.email elie.abinader@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://ajcn.nutrition.org/content/103/5/1327.short en_US

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