Ultrasonographic Development of the Fetal Sheep Stomach and Evaluation of Early Gestation Ultrasound-guided In Utero Intragastric Injection

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dc.contributor.author Abi Nader, Khalil
dc.contributor.author David, Anna L.
dc.contributor.author Weisz, Boaz
dc.contributor.author Steven Shaw, S. W.
dc.contributor.author Themis, Michael
dc.contributor.author Cook, Terence
dc.date.accessioned 2016-06-08T11:22:46Z
dc.date.available 2016-06-08T11:22:46Z
dc.date.copyright 2010 en_US
dc.identifier.issn 1028-4559 en_US
dc.identifier.uri http://hdl.handle.net/10725/3983
dc.description.abstract Objective Safely targeting the fetal gastrointestinal tract during early gestation is essential to develop effective prenatal gene therapy for gastrointestinal diseases. In this study, we aimed to characterize the development of the fetal sheep stomach sonographically and to determine the optimum gestational age, as well as the shortterm morbidity and mortality of early-gestation ultrasound-guided intragastric injection. Materials and Methods In experiments investigating ultrasound-guided prenatal gene therapy, we studied the size and development of the stomach of 185 sheep fetuses (33-144 days' gestational age [GA]; term is 145 days). Ultrasound-guided intragastric injection was performed in 12 fetuses at 55-62 days' GA and postmortem examinations were performed 48 hours later. Results The stomach was not visible at or before 40 days' GA, but it was seen in all fetuses at 55 days' GA or more. The anteroposterior, transverse and longitudinal diameters of the stomach increased in a quasi-linear fashion throughout gestation. Intragastric injection was successful in 10 out of the 11 fetuses (91%) injected at 60-62 days' GA, with nine fetuses (91%) surviving this procedure. Conclusion In the early-gestation sheep fetus, ultrasound-guided intragastric injection has a good success rate with a low short-term mortality and morbidity. en_US
dc.language.iso en en_US
dc.title Ultrasonographic Development of the Fetal Sheep Stomach and Evaluation of Early Gestation Ultrasound-guided In Utero Intragastric Injection en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902740 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Taiwanese Journal of Obstetrics and Gynecology en_US
dc.journal.volume 49 en_US
dc.journal.issue 1 en_US
dc.article.pages 23-29 en_US
dc.keywords Fetus en_US
dc.keywords Gene therapy en_US
dc.keywords Injection en_US
dc.keywords Sheep en_US
dc.keywords Stomach en_US
dc.keywords Ultrasound en_US
dc.identifier.doi http://dx.doi.org/10.1016/S1028-4559(10)60004-6 en_US
dc.identifier.ctation David, A. L., Abi-Nader, K. N., Weisz, B., Shaw, S. S., Themis, M., Cook, T., ... & Peebles, D. M. (2010). Ultrasonographic development of the fetal sheep stomach and evaluation of early gestation ultrasound-guided in utero intragastric injection. Taiwanese Journal of Obstetrics and Gynecology, 49(1), 23-29. en_US
dc.author.email khalil.abinader@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://www.sciencedirect.com/science/article/pii/S1028455910600046 en_US

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