Telemetric monitoring of fetal blood pressure and heart rate in the freely moving pregnant sheep

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dc.contributor.author Abi Nader, Khalil
dc.contributor.author Mehta, Vedanta
dc.contributor.author Steven Shaw, S. W.
dc.contributor.author Bellamy, Tom
dc.contributor.author Smith, Neil
dc.contributor.author Millross, Laura
dc.date.accessioned 2016-06-08T11:02:09Z
dc.date.available 2016-06-08T11:02:09Z
dc.date.copyright 2011 en_US
dc.identifier.issn 0023-6772 en_US
dc.identifier.uri http://hdl.handle.net/10725/3981
dc.description.abstract Remote telemetric monitoring of fetal haemodynamics in pregnant sheep would allow unrestricted animal movement, minimize suffering and distress, and improve animal welfare, while enhancing the quality of data collected. This may also be useful in clinical practice following fetal surgery. Using an open fetal surgical technique at approximately two-thirds of gestation, we implanted the catheter of a D70-PCTP haemodynamic telemetric device (Data Sciences International, Tilburg, The Netherlands) into the carotid artery of the fetal sheep (n ¼ 4). The attached transmitter was secured to the posterior aspect of the maternal anterior abdominal wall. Two receivers, with a range of 1 m each, were sited in an 11 m2 sheep enclosure to maximize animal freedom while allowing continuous monitoring of the ewe. The receivers were connected by cable to a nearby computer. In the first two procedures, both fetuses died eight and 12 days after surgery, and the catheter tip was observed to be lying in the bicarotid trunk. In the next two procedures the catheter tip was threaded further upstream from the insertion point, in an attempt to reach the fetal aorta, and both fetuses survived until the scheduled postmortem examination at the end of pregnancy. After catheter implantation, fetal blood pressure (BP) and heart rate (HR) were successfully recorded continuously for seven days and then hourly per day for a further three weeks. The fetal BP and HR values were in the normal range for healthy sheep fetuses. en_US
dc.language.iso en en_US
dc.title Telemetric monitoring of fetal blood pressure and heart rate in the freely moving pregnant sheep en_US
dc.type Article en_US
dc.description.version Published en_US
dc.title.subtitle a feasibility study en_US
dc.author.school SOM en_US
dc.author.idnumber 200902740 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal Laboratory Animals en_US
dc.journal.volume 45 en_US
dc.journal.issue 1 en_US
dc.article.pages 50-54 en_US
dc.keywords Telemetry en_US
dc.keywords Open fetal surger en_US
dc.keywords Pregnancy en_US
dc.keywords Sheep en_US
dc.keywords Refinement en_US
dc.identifier.doi http://dx.doi.org/10.1258/la.2010.010059 en_US
dc.identifier.ctation Abi-Nader, K. N., Mehta, V., Shaw, S. S., Bellamy, T., Smith, N., Millross, L., ... & David, A. L. (2011). Telemetric monitoring of fetal blood pressure and heart rate in the freely moving pregnant sheep: a feasibility study. Laboratory animals, 45(1), 50-54. en_US
dc.author.email khalil.abinader@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url http://lan.sagepub.com/content/45/1/50.full.pdf+html en_US

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