Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model

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dc.contributor.author Abi Nader, Khalil
dc.contributor.author Nassar, Anwar H.
dc.contributor.author Masrouha, Karim Z.
dc.contributor.author Itani, Hana
dc.contributor.author Usta, Ihab M.
dc.date.accessioned 2016-06-08T09:30:11Z
dc.date.available 2016-06-08T09:30:11Z
dc.date.copyright 2012 en_US
dc.date.issued 2016-06-08
dc.identifier.issn 0735-1631 en_US
dc.identifier.uri http://hdl.handle.net/10725/3978
dc.description.abstract Objective To assess the effect of sildenafil citrate in a rat model of Nω-nitro-l-arginine methyl ester (L-NAME)-induced intrauterine growth restriction (IUGR). Study Design An in vivo experimental study was conducted where 40 pregnant Sprague-Dawley rats were randomly assigned to receive either: (1) control, (2) L-NAME 50 mg/kg/d by gavage (days 14 to 19), (3) L-NAME and sildenafil 15 mg/kg/d by gavage, or (4) sildenafil (days 14 to 21). On day 21, a hysterotomy was performed and all fetuses (live and dead) were counted, examined, and weighed. The primary outcome measure was the difference in pup birth weight. Results The median number of live pups per dam was 11.5 (range: 1 to 15), 13.5 (2 to 17), 13.5 (7 to 16), and 11.5 (4 to 17) in controls, L-NAME, sildenafil, and combined drug groups, respectively (p = 0.02). Rats treated with L-NAME had a significantly higher number of stillbirths compared with control (p = 0.013) and sildenafil (p = 0.008) groups. L-NAME reduced pup birth weight compared with controls (4.53 ± 1.49 versus 5.65 ± 1.63 g, p < 0.001); this effect was more pronounced in the L-NAME and sildenafil groups (3.37 ± 1.25 g, p < 0.001). Conclusion Our data indicate that sildenafil citrate does not ameliorate L-NAME-induced IUGR, and in the doses utilized in this study might even have a synergistic negative effect on pup birth weight. en_US
dc.language.iso en en_US
dc.title Effects of Sildenafil in Nω-Nitro-l-Arginine Methyl Ester–Induced Intrauterine Growth Restriction in a Rat Model en_US
dc.type Article en_US
dc.description.version Published en_US
dc.author.school SOM en_US
dc.author.idnumber 200902740 en_US
dc.author.department N/A en_US
dc.description.embargo N/A en_US
dc.relation.journal American journal of perinatology en_US
dc.journal.volume 29 en_US
dc.journal.issue 6 en_US
dc.article.pages 429-434 en_US
dc.keywords Intrauterine growth restriction en_US
dc.keywords Preeclampsia en_US
dc.keywords Rat model en_US
dc.keywords Sildenafil citrate en_US
dc.keywords L-NAME en_US
dc.identifier.doi http://dx.doi.org/10.1055/s-0032-1304823 en_US
dc.identifier.ctation Nassar, A. H., Masrouha, K. Z., Itani, H., Nader, K. A., & Usta, I. M. (2012). Effects of sildenafil in Nω-nitro-L-arginine methyl ester-induced intrauterine growth restriction in a rat model. American journal of perinatology, 29(6), 429. en_US
dc.author.email khalil.abinader@lau.edu.lb en_US
dc.identifier.tou http://libraries.lau.edu.lb/research/laur/terms-of-use/articles.php en_US
dc.identifier.url https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0032-1304823 en_US

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